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Investigating the preventive effects of oral and intravenous ondansetron on postoperative nausea and vomiting

Comparison of the preventive effects of oral and intravenous ondansetron on postoperative nausea and vomiting in candidate patients undergoing elective laparoscopic cholecystectomy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250107064314N1
Enrollment
60
Registered
2025-01-13
Start date
2025-02-18
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Candidate patients for selective laparoscopic cholecystectomy.

Interventions

Intervention 1: Intervention group: One group will receive a 4 mg oral ondansetron one hour before surgery. Intervention 2: Intervention group: The other group will be injected with 4 mg of intravenou

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: Female patient in the age group of 20 to 40 years ASA class one and two under laparoscopic cholecystectomy surgery

Exclusion criteria

Exclusion criteria: Pregnant patients Has a history of previous abdominal surgery drug addict Body mass index above 30 Patients treated with drugs that increase the QT interval Patients who have taken steroids in the last week

Design outcomes

Primary

MeasureTime frame
Severe nausea and vomiting after surgery. Timepoint: After the operation, the severity of nausea and vomiting is measured and recorded every two hours (2 and 4 hours after the operation). Method of measurement: These variables are measured using the 0-5 PNV (Psychometric of Nausea & Vomiting Scale) scale, in which a score of zero means no nausea and a score of 5 indicates the greatest severity of nausea and vomiting.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Shahryar Sane

Oroumia University of Medical Sciences

shahryarsane@yahoo.com+98 44 3346 9931

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026