Headache.
Conditions
Interventions
Intervention 1: Intervention group: The study duration was designed for 4 months, which included a one-month run-in period and a three-month treatment trial phase with CoQ10. During the run-in period
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with MS according to the 2017 McDonald criteria who refer to the MS clinic of Kashani Hospital, Isfahan, will be screened in 2025 With headache complaints and migraine diagnosis based on the ICHD-3: The International Classification of Headache Disorders Age 18-50 years
Exclusion criteria
Exclusion criteria: The presence of any other disorder or disease that causes secondary headache (hypothyroidism, anemia, hypercapnia, chronic uncontrolled blood pressure, etc.) Patients who have had a long history of chronic headaches before developing MS Taking CoQ10 or other antioxidant supplements within the past 3 months Taking medications, including contraceptives, vasodilators, nitrates, and any medication that increases migraine headaches Pregnancy, breastfeeding and menopause Smoking, NSAID use, or any opioid drugs History of stroke, heart attack, and psychiatric illness Stages of disability so severe that the patient is unable to cooperate in taking a detailed history MS relapse within 30 days of starting medication Any type of allergic reaction after taking the drug The patient's unwillingness to continue participating in the study or their lack of cooperation in taking the medication on time
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity and number of headache attacks. Timepoint: At the start of the study and after one month of treatment. Method of measurement: HIT-6 questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression. Timepoint: When starting after one month of treatment. Method of measurement: Beck score. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Reza Shokrani Foroshani
Esfahan University of Medical Sciences
Outcome results
None listed