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Comparison of two solutions used during hydatid cyst surgery to prevent disease recurrence

Comparison of chlorhexidine gluconate 0.04% with hypertonic saline as a scolcidal agent during liver hydatid surgery and the recurrence of hydatid cyst

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250105064277N2
Enrollment
40
Registered
2026-04-22
Start date
2026-04-30
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatic hydatid cyst

Interventions

Intervention 1: Group 1: Hypertonic saline group Group 2: Chlorhexidine gluconate at a concentration of 0.04% as a scoliosis agent during liver hydatid cyst surgery
topical application within the surgical field and cystic cavity according to standard open surgical technique
once during surgery. Intervention 2: Intervention group: Hypertonic saline as a scolicidal agent during hepatic hydatid cyst surgery
topical application in the operative field and cyst cavity
single use during surgery.

Sponsors

Shahre-kord University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with hepatic hydatid cysts with an indication for surgery Willingness to participate in the study and provision of informed consent Age between 18 and 65 years No contraindication to surgery

Exclusion criteria

Exclusion criteria: Patients with severe concomitant systemic diseases History of hypersensitivity to chlorhexidine gluconate Patients with recurrent hydatid cysts Patients undergoing reoperation for hydatid cyst Lack of cooperation or refusal to participate in the study Use of albendazole prior to surgery

Design outcomes

Primary

MeasureTime frame
Proportion of patients with recurrent hepatic hydatid cyst detected by CT scan within 6 months after surgery. Timepoint: 6-month postoperative follow-up. Method of measurement: Computed Tomography imaging of the liver for detection of hydatid cyst recurrence.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRasoul Rahimi

Shahre-kord University of Medical Sciences

rahimi.r@skums.ac.ir+98 38 3226 4841

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026