Investigating the effect of herbal mouthwash and chlorhexidine in the treatment of chronic periodontitis

Investigation of effect of Dena dent biological and chlorhexidine mouthwashes on level of Tumor necrosis factor alpha(TNF-a) and (IL-1ß) in chronic periodontitis patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20250104064271N1

Enrollment

Registered

2025-01-22

Start date

2025-03-04

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group: Receiving 10 ml Dena dent herbal mouthwash twice a day for 14 days. Intervention 2: Control group: receiving 0.2% chlorhexidine mouthwash at the rate of 10 ml twice

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients diagnosed with chronic periodontitis by the dentists Patients' consent to participate in the study

Exclusion criteria

Exclusion criteria: Use of antibiotics or periodontal medications one month prior to the study Having diabetes or any type of systemic disease Pregnancy and breastfeeding Allergies Sensitivity to mouthwashes Smoking Presence of pathological lesions in the oral mucosa Having dental prostheses or orthodontic appliances Having tooth discoloration due to systemic factors History of alcohol consumption in the past 4 months

Design outcomes

Primary

Measure	Time frame
Interleukin 1 beta. Timepoint: Before the intervention and 14 days after the intervention. Method of measurement: Elisa reader device.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Ebadi Moghaddam

Yasouj University of Medical Sciences

Erfanallii212@gmail.com+98 917 880 8513

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026