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A comparative study of the effect of prodrug ketamine and dexamethasone on pain and nausea and vomitting in patients after gastric bypass laparoscopic surgery

A Comparative Study of the Effect of Prodrug Ketamine and Dexamethasone on Pain and Nausea and Vomitting in Patients after Gastric Bypass Laparoscopic Surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20250101064240N1
Enrollment
102
Registered
2025-04-06
Start date
2025-05-22
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Nausa, Vomitting, Gastric bypass laparoscopic surgery.

Interventions

Intervention 1: Intervention group: The first intervention group receives 0.75 mg of ketamine per kilogram of weight. The drug is administered as a single intravenous dose during surgery. Intervention

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Diagnosis of laparoscopic abdominal surgery (the patient or doctor has chosen laparoscopic gastric bypass for weight loss) Age over 18 years and under 65 years Informed consent to participate in the study Patients who are candidates for surgery under general anesthesia Patients who are candidates for laparoscopic gastric bypass surgery with a BMI above 40

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Pain. Timepoint: Upon entering recovery and every fifteen minutes until exiting recovery. Method of measurement: Pain measurement using the visual analogue scale method gives the necessary score according to the severity of the pain (0 means none, from 1 to 3 means mild, from 4 to 6 means moderate, from 7 to 10 means severe).;Nausa. Timepoint: Upon entering recovery and every fifteen minutes until exiting recovery. Method of measurement: Grades of nausea: 0 = no nausea1 =mild nausea, not requesting pharmacological rescue2 = nausea, requesting pharmacological rescue3 = nausea, resistant to pharmacological treatment.;Vomitting. Timepoint: Upon entering recovery and every fifteen minutes until exiting recovery. Method of measurement: Grades of vomiting:0 = no vomiting1 =vomiting, single event2 =vomiting, repeated events, requesting pharmacological rescue3 = vomiting, resistant to pharmacological treatment.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNiloofar Jalalpour

Esfahan University of Medical Sciences

niloofar.jalalpour@gmail.com+98 31 3621 8027

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026