Effect of Ticagrelor on Aortic Stiffness

Effect of Ticagrelor Versus Clopidogrel on Aortic Stiffness in Patients Underwent Angioplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241231064227N1

Enrollment

Registered

2025-05-28

Start date

2025-06-05

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Artery Disease (PAD).

Interventions

Intervention 1: Intervention group: Patients receiving Ticagrelor, 90 mg twice daily and Aspirin 80mg Daily, for one month. Intervention 2: Control group: Patients receiving Clopidogrel, 75mg daily an

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Diagnosis of PAD Angioplasty Taking Clopidogrel or Ticagrelor Informed consent

Exclusion criteria

Exclusion criteria: Prior history of Vascular surgery on the same limb

Design outcomes

Primary

Measure	Time frame
Aortic stiffness. Timepoint: At the beginning of the study and after one month of consumption of Clopidogrel or Ticagrelor. Method of measurement: Palse Wave Velocity marker by AngE ABI testing device.;Vascular events - Diabetic foot. Timepoint: At the beginning of the study and after one month of consumption of Clopidogrel or Ticagrelor. Method of measurement: Diabetic foot grading based on Wagner scale.;Vascular events - Rest pain. Timepoint: At the beginning of the study and after one month of consumption of Clopidogrel or Ticagrelor. Method of measurement: VAS Score.	—

Measure

Time frame

Aortic stiffness. Timepoint: At the beginning of the study and after one month of consumption of Clopidogrel or Ticagrelor. Method of measurement: Palse Wave Velocity marker by AngE ABI testing device.;Vascular events - Diabetic foot. Timepoint: At the beginning of the study and after one month of consumption of Clopidogrel or Ticagrelor. Method of measurement: Diabetic foot grading based on Wagner scale.;Vascular events - Rest pain. Timepoint: At the beginning of the study and after one month of consumption of Clopidogrel or Ticagrelor. Method of measurement: VAS Score.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPouya Tayebi

Babol University of Medical Sciences

p.tayebi@yahoo.com+98 11 3223 8308

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026