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Evaluation of the Effect of Vitamin C and Oxycodone on Complex Regional Pain Syndrome (CRPS) in Patients with Distal Radius Fractures

Evaluation of vitamin C and oxycodone on Complex Regional Pain Syndrome (CRPS) in patients with distal radius fractures who underwent surgery with pin placment and cast.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241230064213N1
Enrollment
120
Registered
2025-01-04
Start date
2024-04-08
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complex Regional Pain Syndrome (CRPS). Complex regional pain syndrome I (CRPS I)

Interventions

Intervention 1: Intervention group1: Patients in this group will receive 500 mg of Vitamin C daily for 8 weeks. Intervention 2: Intervention group2: Patients in this group will receive 5 to 10 mg of O

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: All patients with distal radius fractures who are treated with closed reduction, pinning, and splinting or plaster casting Patient consent to participate in the study

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
The intensity of patients’ pain will be measured using the Visual Analogue Scale (VAS) at different time intervals. The aim is to assess the reduction in pain intensity and the occurrence of Complex Regional Pain Syndrome (CRPS). Timepoint: The time intervals for assessment will include the 2nd, 4th, 6th, and 8th weeks after the start of the intervention. Method of measurement: Pain intensity will be measured using the Visual Analogue Scale (VAS) ranging from 0 to 10. The occurrence of CRPS will also be assessed based on clinical symptoms and standard diagnostic criteria.

Secondary

MeasureTime frame
The hand function of patients will be assessed using the Quick DASH questionnaire.(Quick Disabilities of the Arm, Shoulder and Hand). Timepoint: The time intervals for assessment will include the 2nd, 4th, 6th, and 8th weeks after the start of the intervention. Method of measurement: The hand function of patients will be assessed using the “Quick Disabilities of the Arm, Shoulder and Hand (Quick DASH)” questionnaire. This self-reported tool evaluates daily hand functionality and pain levels through patient responses.;Vasomotor symptoms, including temperature and blood flow changes, will be assessed. Timepoint: The time intervals for assessment will include the 2nd, 4th, 6th, and 8th weeks after the start of the intervention. Method of measurement: Vasomotor symptoms, including changes in temperature and blood flow, will be assessed clinically. Temperature changes will be measured using a skin thermometer, and blood flow changes will be evaluated through color and capillary refill assessment.;Pseudomotor symptoms, including abnormal sweating, will be evaluated. Timepoint: The time intervals for assessment will include the 2nd, 4th, 6th, and 8th weeks after the start of the intervention. Method of measurement: Pseudomotor symptoms, including abnormal sweating and skin changes, will be assessed through clinical examination and direct observation.;Swelling of the hands will be evaluated. Timepoint: The time intervals for assessment will include the 2nd, 4th, 6th, and 8th weeks after the start of the intervention. Method of measurement: Swelling in the affected area will be measured by circumferential measurements of the injured limb (hand) using a measuring tape.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmin Fathi

Iran University of Medical Sciences

aminfathi23@gmail.com+98 21 6435 2368

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026