Comparing Different Therapeutic Approaches for Treating Obsessive-Compulsive Disorder in Iranian Adults Based on Genetic and Individual Sensitivity Factors

Comparison of the Efficacy and Effectiveness of Cognitive Behavioral Therapy (CBT), Acceptance and Commitment Therapy (ACT), Metacognitive Therapy (MCT), and Dialectical Behavior Therapy (DBT) in Treating Obsessive-Compulsive Disorder Among Iranian Adults Considering Genetic Data and the Vantage Sensitivity Model: A Scientific Approach to Personalized Treatment Selection

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241229064211N1

Enrollment

100

Registered

2025-02-22

Start date

2025-01-29

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obsessive-Compulsive Disorder. Obsessive-compulsive disorder

Interventions

Intervention 1: Intervention Group 1: Cognitive Behavioral Therapy (CBT):This intervention follows the Exposure and Response Prevention (ERP) protocol and targets maladaptive beliefs associated with O

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Definite diagnosis of Obsessive-Compulsive Disorder (OCD) based on the Structured Clinical Interview for DSM-5 (SCID-5). Age between 18 and 60 years. Presence of specified genetic polymorphisms associated with treatment sensitivity (e.g., -HTTLPR 5 and BDNF). Willingness and ability to provide a saliva sample for genetic analysis and cortisol measurement. Ability to read, understand, and complete questionnaires and participate in therapy sessions. No psychological or pharmacological treatment for OCD in the past three months. Signed informed consent for study participation.

Exclusion criteria

Exclusion criteria: Presence of severe comorbid psychiatric disorders such as schizophrenia, bipolar disorder type I, or major depression with suicidal thoughts. Substance abuse or alcohol dependence. Receipt of psychological or pharmacological treatment for OCD in the past three months. Pregnancy or possibility of pregnancy. Severe physical or chronic illnesses that may interfere with the study process or outcomes. Inability to complete assessment tools due to language, cognitive, or educational limitations.

Design outcomes

Primary

Measure	Time frame
Primary Outcome Variable: Severity of Obsessive-Compulsive Disorder (OCD) symptoms.Measurement Method: The severity of symptoms will be assessed using the Obsessive-Compulsive Inventory-Revised (OCI-R). This validated tool evaluates the severity and types of obsessive-compulsive symptoms. Timepoint: Assessment Time Points: Pre-test (before the intervention), post-test (immediately after completing the intervention), and six-month follow-up (to assess the sustainability of changes). Method of measurement: Severity of Obsessive-Compulsive Disorder (OCD) Symptoms:This variable will be measured using the Obsessive-Compulsive Inventory-Revised (OCI-R). The tool consists of 18 items across six subscales (obsessions, compulsions, washing, hoarding, ordering, and neutralizing), rated on a 5-point Likert scale (0 = never to 4 = always).Salivary Cortisol Levels:Saliva samples will be collected at three time points (pre-test, post-test, and six-month follow-up) and analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) method to determine cortisol levels as a physiological stress marker.Psychological and Metacognitive Characteristics:Psychological characteristics, such as psychological flexibility and sensitivity to environmental stimuli, will be assessed using validated tools like the NEO Five-Factor Inventory (NEO-FFI) and the Highly Sensitive Person Scale (HSP) by Aron.All measurements will be conducted by trained professionals using standardized scientific methods to ensure data accuracy and reliability.	—

Measure

Time frame

Primary Outcome Variable: Severity of Obsessive-Compulsive Disorder (OCD) symptoms.Measurement Method: The severity of symptoms will be assessed using the Obsessive-Compulsive Inventory-Revised (OCI-R). This validated tool evaluates the severity and types of obsessive-compulsive symptoms. Timepoint: Assessment Time Points: Pre-test (before the intervention), post-test (immediately after completing the intervention), and six-month follow-up (to assess the sustainability of changes). Method of measurement: Severity of Obsessive-Compulsive Disorder (OCD) Symptoms:This variable will be measured using the Obsessive-Compulsive Inventory-Revised (OCI-R). The tool consists of 18 items across six subscales (obsessions, compulsions, washing, hoarding, ordering, and neutralizing), rated on a 5-point Likert scale (0 = never to 4 = always).Salivary Cortisol Levels:Saliva samples will be collected at three time points (pre-test, post-test, and six-month follow-up) and analyzed using the Enzyme-Linked Immunosorbent Assay (ELISA) method to determine cortisol levels as a physiological stress marker.Psychological and Metacognitive Characteristics:Psychological characteristics, such as psychological flexibility and sensitivity to environmental stimuli, will be assessed using validated tools like the NEO Five-Factor Inventory (NEO-FFI) and the Highly Sensitive Person Scale (HSP) by Aron.All measurements will be conducted by trained professionals using standardized scientific methods to ensure data accuracy and reliability.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAbbas Bakhshipour Roudsari

University of Tabriz

abbas.bakhshipour@gmail.com+98 41 3334 0081

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026