Acute Ischemic Stroke.
Conditions
Interventions
Intervention 1: Intervention group: Melatonin 3 mg (one pill every night for two weeks),. Intervention 2: Control group:Placebo (one pill every night for two weeks).
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 18 to 80 years Informed consent will be obtained from individuals who are capable of completing the consent form themselves; otherwise, it will be obtained from their companions. Acute stroke incident that occurred within 7 days prior to admission Diagnosis of acute ischemic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI) at the time of admission Patients who have not received alteplase
Exclusion criteria
Exclusion criteria: No history of stroke Primary hemorrhagic stroke Pre-stroke diagnosis of cognitive decline or significant impairment A valid neurological disease in addition to stroke, such as Parkinson's disease Severe liver, kidney, or thyroid diseases, or heart failure, respiratory failure, or other organ failures Chronic inflammatory diseases, immune disorders, or hematologic disorders History of depression (clinical diagnosis or previous treatment) or other psychiatric disorders Severe visual impairment, inability to speak, or hearing impairment that may affect cognitive assessment. History of the use of nootropic or antipsychotic medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement Cognitive Impairment. Timepoint: Before and after the intervention. Method of measurement: Cognitive performance will be assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) within 2 weeks after the stroke. The scores for MMSE and MoCA range from 0 to 30, with higher scores indicating better cognitive performance. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Rizvan Norouzzadeh
Oroumia University of Medical Sciences
Outcome results
None listed