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intrauterine insemination of Peripheral blood mononuclear cells on clinical outcomes in women with repeated implantation failure

Investigating the effectiveness of intrauterine insemination of Peripheral blood mononuclear cells on clinical outcomes in women with repeated implantation failure

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241225064169N1
Enrollment
100
Registered
2025-01-05
Start date
2025-01-20
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Intervention group: "In the study group, blood samples (16 to 20 milliliters) will be taken from patients on day 1, and PBMCs will be isolated using centrifugation. After centrifugatio

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: All patients have had three or more repeated implantation failures in IVF-ET treatment Age < 40

Exclusion criteria

Exclusion criteria: Patient's immune deficiency Unwillingness to cooperate and participate in the study Patients suffering from disorders such as: hydrosalpinx, Asherman syndrome, organic endometrial disease, chromosomal abnormalities and severe endometriosis, chromosomal abnormalities, presence of antiphospholipid antibodies, mutations related to coagulation system parts, such as deficiency of factor XII, protein C, and protein S Patients with thin endometrium (endometrium less than 7 mm on the day of ET)

Design outcomes

Primary

MeasureTime frame
Performing pregnancy tests and follow-up ultrasound for pregnancy diagnosis. Timepoint: Pregnancy test 12 days after ET and 30 days after a positive pregnancy test. Method of measurement: Blood test.;Observing the number and location of gestational sacs. Timepoint: 30 days after a positive pregnancy test. Method of measurement: TVS.

Secondary

MeasureTime frame
Live birth. Timepoint: After delivery. Method of measurement: Clinical.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactRaha Karami

Shiraz University of Medical Sciences

Karami.Rahapz90@gmail.com0098712332365

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026