Urogenital syndrome includes symptoms such as burning, itching, vaginal dryness, and dyspareunia.. Candidiasis of other urogenital sites
Conditions
Interventions
Intervention 1: Intervention group: The group receiving the Lactobacillus-containing cream.To prepare the cream, based on the weight of the Lyophilized Lactobacillus powder provided to us by ZistTakhm
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Postmenopausal women who have had at least 12 months since their last menstrual period Have at least one of the following symptoms: burning sensation in the urethra or vaginal burning, vaginal dryness, dyspareunia, and urinary frequency Normal urine test in the presence of urinary symptoms Having a normal mammogram
Exclusion criteria
Exclusion criteria: Presence of vaginal infection and discharge during examination Antibiotic use within one month of the study History of breast cancer or other estrogen-dependent cancers Presence of vaginal lesions other than scarring or erosion associated with atrophy History of thromboembolic events Use of injectable systemic estrogen within six months prior to the study Use of androgens or anabolic steroids within 6 months prior to the study Use of oral estrogen, progesterone, or DHEA-containing compounds within 8 weeks prior to the study Use of vaginal hormonal products (ring, cream, gel, or pill) or transdermal estrogen alone or in combination with progesterone within 8 weeks prior to the study History of endometrial cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urogenital syndrome includes symptoms such as burning, itching, vaginal dryness, and dyspareunia. Timepoint: 4 week. Method of measurement: Symptoms related to vulvovaginal and urogenital atrophy are assessed using the standard Menopause Rating Scale (MRS) questionnaire.;Menopause symptom severity grading. Timepoint: 1 day. Method of measurement: Menopause symptom severity scale questionnaire.;Vaginal health (elasticity, discharge, mucosal condition, moisture). Timepoint: 1 day. Method of measurement: To assess vaginal health objectively, the Vaginal Health Index (VHI) will be used, which includes evaluation of five parameters: elasticity, discharge, vaginal pH, mucosal condition, and moisture. This assessment will be conducted at both the beginning and the end of the study. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsieh Maleki
Mashhad University of Medical Sciences
Outcome results
None listed