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Investigation the effect of Origanum vulgare vaginal cream on treatment of vulvovaginal candidiasis

Comparison the effect of Origanum vulgare vaginal cream with clotrimazole vaginal cream on treatment of vulvovaginal candidiasis in reproductive aged women

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241221064119N1
Enrollment
98
Registered
2024-12-25
Start date
2025-04-19
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vulvovaginal candidiasis. Candidiasis of vulva and vagina

Interventions

Intervention 1: Intervention Group: In the intervention group, when administering the medication, necessary hygiene instructions will be provided to the patients. These instructions include: wearing c

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Being married Being monogamous The presence of clinical symptoms indicative of vulvovaginal candidiasis Positive result of the direct microscopy test of vaginal discharge Positive result of the vaginal discharge culture test No history of any known medical condition No allergy to Origanum vulgare plant and clotrimazole Completion of a written informed consent form

Exclusion criteria

Exclusion criteria: Pregnancy Breastfeeding Menopause Abnormal vaginal bleeding Body mass index (BMI) = 30 History of recurrent vulvovaginal candidiasis infections (4 or more episodes per year) History of known chronic diseases such as diabetes, hypertension, heart disease, immune system disorders and epilepsy Use of broad-spectrum antibiotics within the past two weeks Use of immunosuppressive drugs, corticosteroids or contraceptive pills Use of oral or vaginal medications related to genital infections within the past two weeks

Design outcomes

Primary

MeasureTime frame
Vaginal discharge. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Taking the patient's history and clinical examination.;Vaginal pH. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: pH indicator strips.;Gram staining of vaginal discharge smear test. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Gram staining of vaginal discharge smear.;Vaginal discharge culture. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Vaginal discharge culture on CHROMagar candida medium.;Complete recovery from vulvovaginal candidiasis. Timepoint: One week after completing the treatment course. Method of measurement: Taking the patient's history, clinical examination, Gram staining of vaginal discharge smear and vaginal discharge culture on CHROMagar candida medium.;Vulvovaginal itching. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Taking the patient's history.;Vulvovaginal erythema. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Clinical examination.;Vulvovaginal burning. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Taking the patient's history.

Secondary

MeasureTime frame
Urinary burning. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Taking the patient's medical history.;Dyspareunia. Timepoint: Before the intervention and one week after completing the treatment course. Method of measurement: Taking the patient's medical history.;Side effects. Timepoint: One week after completing the treatment course. Method of measurement: Taking the patient's medical history.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Shahriari

Ahvaz University of Medical Sciences

fatemeh.shah9675@gmail.com+98 916 634 9502

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026