Effect of injection of Lidocaine and epinephrine solution in septorhinoplasty surgery

Comparison of the effect of injection of Lidocaine and epinephrine solution in nasal areas on blood pressure and heart rate of patients undergoing septorhinoplasty: Randomized control trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241217064084N1

Enrollment

144

Registered

2025-02-18

Start date

2024-12-30

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Blood pressure in septorhinoplasty patients. Condition 2: Heart rate in septorhinoplasty patients. Encounter for examination of blood pressure Unspecified abnormalities of heart beat

Interventions

Intervention 1: Control group: Eligible patients who during rhinoplasty surgery receive 1.5 cc of 1/100000 lidocaine and epinephrine solution in the septocolumellar area 10 minutes after anesthesia. I

Eligibility

Sex/Gender

All

Age

17 Years to 70 Years

Inclusion criteria

Inclusion criteria: patients 17 to 70 years old candidates for rhinoplasty no drug sensitivity

Exclusion criteria

Exclusion criteria: Exclusion criteria: patients with co-morbidities such as diabetes, thyroid, cardiovascular complications such as ischemic heart disease, active hepatitis antihypertensive and cardiac drug users alcohol dependence operation duration of more than 3 hours atients with anemia

Design outcomes

Primary

Measure	Time frame
Blood pressure level. Timepoint: 10 minutes after creating anesthesia before injection and 10 minutes after injecting 1.5 cc of lidocaine and epinephrine solution into different areas of the nose. Method of measurement: Systolic and diastolic blood pressure: measurement of the blood flow pressure entering the vessel wall using a monitoring device connected to the patient 10 minutes after anesthesia before injection and 10 minutes after injection of 1.5 cc of lidocaine and epinephrine solution into different areas of the nose.;Number of heartbeats. Timepoint: 10 minutes after creating anesthesia before injection and 10 minutes after injecting 1.5 cc of lidocaine and epinephrine solution into different areas of the nose. Method of measurement: Measurement of heart rate using a monitoring device connected to the patient 10 minutes after induction of anesthesia before injection and 10 minutes after injection of 1.5 cc of solution Lidocaine and epinephrine to different areas of the nose.	—

Measure

Time frame

Blood pressure level. Timepoint: 10 minutes after creating anesthesia before injection and 10 minutes after injecting 1.5 cc of lidocaine and epinephrine solution into different areas of the nose. Method of measurement: Systolic and diastolic blood pressure: measurement of the blood flow pressure entering the vessel wall using a monitoring device connected to the patient 10 minutes after anesthesia before injection and 10 minutes after injection of 1.5 cc of lidocaine and epinephrine solution into different areas of the nose.;Number of heartbeats. Timepoint: 10 minutes after creating anesthesia before injection and 10 minutes after injecting 1.5 cc of lidocaine and epinephrine solution into different areas of the nose. Method of measurement: Measurement of heart rate using a monitoring device connected to the patient 10 minutes after induction of anesthesia before injection and 10 minutes after injection of 1.5 cc of solution Lidocaine and epinephrine to different areas of the nose.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamed Mahdavi

Guilan University of medical sciences

hamedmhd0235@gmail.com+98 13 3323 8306

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026