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Investigating the effect of sublingual squalene on children's pneumonia

Investigating the effect of sublingual squalene on the number of hospitalization days due to pneumonia in children hospitalized in intensive care units

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241216064079N1
Enrollment
52
Registered
2025-01-14
Start date
2025-01-04
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pneumonia. Pneumonia, unspecified organism

Interventions

Intervention 1: Intervention group:Intervention group: The demographic, clinical and laboratory and radiological data of 26 people in the intervention group are
age, sex, vital signs, CRP, WBC, Spo2, ESR, lung involvement in chest X-ray, consciousness level, oxygen administration method and PRISM score are collected and evaluated. Subsequently, besides the an

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Months to 18 Years

Inclusion criteria

Inclusion criteria: Completion of the informed consent form by the guardian of the child Diagnosing pneumonia requiring admission to the intensive care unit based on the latest IDSA guidelines for pneumonia in children Two months to 18 years old Absence of immunodeficiency, underlying heart disease, chronic lung disease, underlying metabolic disease, congenital anomalies

Exclusion criteria

Exclusion criteria: Termination of cooperation and lack of follow-up The patient died within 6 days of follow-up

Design outcomes

Primary

MeasureTime frame
The rate of increase in body temperature above 38 degrees. Timepoint: At the beginning of the study and on the second and sixth days. Method of measurement: It is measured with a thermometer.;Increasing the heart rate in groups is considered. Timepoint: Increasing the heart rate in groups is considered. Method of measurement: It is measured by cardiac monitoring.;Increasing the number of breaths in groups is considered. Timepoint: At the beginning of the study and on the second and sixth days. Method of measurement: It is measured by cardiopulmonary monitoring.;Increasing blood oxygenation is considered. Timepoint: At the beginning of the study and on the second and sixth days. Method of measurement: It is measured by pulse oximetry.;The reduction of CRP is considered. Timepoint: The first, second and sixth days of hospitalization. Method of measurement: Send a blood test.;The amount of WBC decrease is considered. Timepoint: At the beginning of the study and on the second and sixth days. Method of measurement: Send a blood test.;The reduction of pulmonary infiltration is considered. Timepoint: At the beginning of the study and the sixth day of treatment. Method of measurement: The radiograph is reported by the radiologist.;GCS. Timepoint: On the first, second, fourth and sixth day of treatment. Method of measurement: The score is given with the help of the Coma Glasgow Score table.

Secondary

MeasureTime frame
Number of days in hospital. Timepoint: It is measured at the end of the study. Method of measurement: The number of hospitalization days is calculated.;Readmission within the next 30 days. Timepoint: One month after discharge. Method of measurement: One month after discharge, the patient's parents are contacted and asked about the re-hospitalization due to pneumonia.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFateme Zaker Tavallaie

Mashhad University of Medical Sciences

ak.pr@mums.ac.ir+98 51 3871 3801

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026