Bone pain induced by G-CSF and its derivatives in children undergoing chemotherapy.
Conditions
Interventions
Intervention 1: Intervention group: At least one hour before receiving filgrastim or its derivatives, Loratadine syrup at the dose of 10 mg daily for one week + Acetaminophen PRN ??mg/kg q?h (if neede
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Age 6 to 18 years Undergoing chemotherapy with an indication for receiving pegfilgrastim or filgrastim Parent or legal guardian consent for participation in the study
Exclusion criteria
Exclusion criteria: Any contraindication for receiving loratadine (e.g., previous allergy to the drug) Concurrent use of antihistamines for any reason or patients who have received antihistamines in the past three days Patients with bone pain due to an underlying condition Patients on a stable regimen of opioids or NSAIDs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in pain score in the first cycle between the two groups. Timepoint: every 24 hours while receiving the intervention or control treatment. Method of measurement: Visual Analogue Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in the number of times painkiller treatment is needed between the two groups. Timepoint: every 24 hours while receiving the intervention or control treatment. Method of measurement: Visual Analogue Scale.;The difference in pain scores in the second cycle between the two groups. Timepoint: every 24 hours while receiving the intervention or control treatment. Method of measurement: Visual Analogue Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Karbasi Kalajahi
Oroumia University of Medical Sciences
Outcome results
None listed