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Review of the effect of using Platelet-Rich Fibrin (PRF) on the development of paresthesia and anesthesia in impacted lower third molar surgery in contact with the nerve

Comparison of the effect of using Platelet-Rich Fibrin (PRF) on the development of paresthesia and anesthesia in impacted lower third molar surgery in contact with the nerve between two groups using PRF and control

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241212064029N1
Enrollment
100
Registered
2025-01-02
Start date
2025-01-09
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

PRF in surgery of impacted wisdom teeth of the lower jaw in contact with the nerve.

Interventions

Intervention 1: Intervention group: In the intervention group, a 10cc blood sample is taken by a trained nurse before surgery and placed in a test tube that does not contain any substance. Then, the t

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients who have at least one of their impacted or partially impacted wisdom tooth roots in contact with the inferior alveolar nerve canal. Patients without uncontrolled systemic problems who fall into ASA classification 1 and 2.

Exclusion criteria

Exclusion criteria: Age below 18 years and above 45 years The possibility of iatrogenic damage to the nerve during surgery Patients with acute pericoronitis and severe pain before surgery Patients taking antidepressant drugs Patients who consume more than 10 cigarettes per day Patients taking any medication that interferes with nerve, muscle and bone repair Horizontal tooth whose crown is very close to the nerve Patients taking osteoporosis drugs such as alendronate Patients with a history of radiotherapy and chemotherapy, less than 1 year has passed since their treatment history

Design outcomes

Primary

MeasureTime frame
Pain, tingling, or numbness of the chin or lower lip, measured by the project manager based on the patient's description and the definition of paresthesia and anesthesia. Timepoint: All patients are examined at 6 hours, 24 hours, 72 hours, and one week after surgery. Patients are followed up for changes in chin and lip sensation at one-month, three-month, and six-month intervals. Method of measurement: Paresthesia is measured by the project manager based on the patient's description and the definition of paresthesia and anesthesia.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAida Karimzadehkan

Mazandaran University of Medical Sciences

A.karimzadegan@gmail.com+98 11 4201 0405

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026