Chronic obstructive pulmonary disease. Other chronic obstructive pulmonary disease
Conditions
Interventions
Intervention 1: Intervention group: The patients in the case group will be prescribed probiotic capsule containing 109 CFU manufactured by Bio Fermentation Company after meals. According to previous s
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with COPD referred to the Special Clinic of Semnan University of Medical Sciences who experienced exacerbation of respiratory symptoms Patients older than 18 years
Exclusion criteria
Exclusion criteria: Patients with other underlying diseases such as pneumonia, acute bronchiolitis, coronary heart diseases, lung cancer, infectious diseases, primary immune system deficiency, secondary immune system deficiency History of allergy to probiotic products Patients who take antibiotics during treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the severity of dyspnea in patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Questionnaire and MMRC criteria.;Changes in the amount of cough in patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Questionnaire and MMRC criteria.;Changes in the amount of sputum in patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Questionnaire and MMRC criteria. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in spirometry factors of patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Spirometry.;The level of IL-6 expression in patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Real-time PCR.;The level of IL-17 expression in patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Real-time PCR.;The level of TGF-ß expression in patients with COPD following the administration of probiotic supplements compared to the control group. Timepoint: Before and 60 days after the start of the intervention. Method of measurement: Real-time PCR. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactRasoul Baharloo
Semnan University of Medical Sciences
Outcome results
None listed