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Investigating methadone treatment with N-acetylcysteine ??on men's sexual performance

Comparison of the effect of Methadone treatment with N-Acetyl cystein on men s sexual dysfunction compared to Methadone

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241211064021N2
Enrollment
112
Registered
2025-01-30
Start date
2025-02-24
Completion date
Unknown
Last updated
2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male sexual performance-Male erectile dysfunction. Sexual dysfunction, not caused by organic disorder or disease

Interventions

Intervention 1: In the intervention group, N-acetylcysteine ??tablets with a dose of 2400 mg manufactured in Oh Sina Pharmaceutical Company 2 times a day are added to methadone maintenance treatment f

Sponsors

Hamedan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: The presence of sexual activity (such as intercourse, caressing a partner without having sex, foreplay and masturbation) in the last 4 weeks under MMT treatment More than 8 weeks under methadone maintenance treatment. Consent to participate in the study

Exclusion criteria

Exclusion criteria: People who had a history of erectile dysfunction and used drugs for erection such as diuretics, anticholinergic and antipsychotic drugs, phosphodiesterase 5 inhibitors Patients who have a history of cardiovascular problems based on arteriosclerosis and peripheral vascular diseases

Design outcomes

Primary

MeasureTime frame
Determining the effect of methadone treatment along with N-acetylcysteine ??on men's sexual performance compared to methadone treatment. Timepoint: Determining and comparing the level of sexual dysfunction before and 12 weeks after receiving methadone + N-acetylcysteine. Method of measurement: Questionnaires of depression, sexual function, and cognitive function are completed for patients before and 12 weeks after treatment.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMena Dostizadeh

Hamedan University of Medical Sciences

mandanasafishahi@gmail.com+98 81 3131 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026