Comparison of the effect of topical permethrin gel %5 with glycerin -alcohol mixture on acne with Demodex Folliculorum

Determining and comparing the therapeutic effect of 5% permethrin topical gel with glycerin -alcohol mixture on acne associated with demodex follicularum.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241209064003N1

Enrollment

Registered

2025-05-18

Start date

2025-03-27

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rosacea. Rosacea

Interventions

Intervention 1: Intervention group: Each patient randomly applied glycerin -alcohol mixture on one side of his/her face on clean skin twice a day for 12 weeks. Intervention 2: Control group: Each pat

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Criteria for entering the study of patients with papulopustular rosacea; The presence of at least 5 demodex mites per square cm in both skin biopsy samples on the left and right sides of the face Patients over 18 years of age, regardless of their gender

Exclusion criteria

Exclusion criteria: Exclusion criteria for patients with rosacea with less than 5 demodex mites per square cm in the skin biopsy sample of one or both left and right sides of the face of patients with various types of skin cancers non-compliance with the protocol History of allergy to permethrin Patients with severe skin burns Patients with severe skin infections

Design outcomes

Primary

Measure	Time frame
Demodex mite density in one square centimeter of the face skin surface on the left and right side. Timepoint: Weeks 0 and 12 on the left and right side of the face. Method of measurement: Demodex mite density in one square cm of the facial skin surface was determined using standard skin biopsy technique at 0 and 12 weeks on the left and right side of the face.	—

Secondary

Measure	Time frame
Clinical and appearance symptoms of rosacea patients include: transient redness, persistent redness, papule and pustule, telangiectasia, burning and itching, plaque, dryness, edema, eye symptoms, phymatous changes. Timepoint: Weeks 0 and 12 on the left and right side of the face. Method of measurement: Appearance and clinical symptoms of patients were evaluated in weeks 0 and 12 by the clinical criteria mentioned in the National Rosacea Association questionnaire for both sides of the face.	—

Measure

Time frame

Clinical and appearance symptoms of rosacea patients include: transient redness, persistent redness, papule and pustule, telangiectasia, burning and itching, plaque, dryness, edema, eye symptoms, phymatous changes. Timepoint: Weeks 0 and 12 on the left and right side of the face. Method of measurement: Appearance and clinical symptoms of patients were evaluated in weeks 0 and 12 by the clinical criteria mentioned in the National Rosacea Association questionnaire for both sides of the face.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Sobhan Mohammadi Mahvizani

Artesh University of Medical Sciences

sobhan.mhm96@gmail.com+98 21 8609 6350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026