Obesity. Overweight and obesity
Conditions
Interventions
Intervention 1: Intervention group: The synbiotic supplement BioGen®, manufactured by Tak Gene Zist, contains strains of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus plantarum, St
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Adults (18 to 65 years old) who, according to NIH guidelines, have class 3 obesity or class 2 obesity with at least one obesity-related co-morbidity and have undergone SG surgery within the past month Willingness to adhere to supplement intake and follow-up programs
Exclusion criteria
Exclusion criteria: Pregnant or lactating women Patients consuming other probiotic/prebiotic supplements, taking antibiotics up to 10 days before the start of the intervention, or using medications that affect gut microbiota The presence of severe malabsorption syndromes unrelated to surgery (inflammatory bowel disease, celiac disease, etc.) Presence of previous nutritional deficiencies Presence of any gastrointestinal diseases Presence of surgical complications (such as fistula at the incision site, gastrointestinal bleeding, intestinal obstruction, etc.) Unable to comprehend the purpose of evaluations or the proposed treatment Patients who refuse to participate in the study until its completion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Ferritin. Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: immunoassay.;Serum Folate. Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: Radioimmunoassay.;Serum total Calcium. Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: colorimetry.;Serum 25-hydroxy vitamin D. Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: immunoassay.;Serum vitamin B12. Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: Electrochemiluminescence.;Serum Iron. Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: spectrophotometry.;TIBC (Total Iron-Binding Capacity). Timepoint: Before the start of the intervention, and 3 and 6 months after the intervention begins. Method of measurement: spectrophotometry. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammadmahdi Abbasi
Tehran University of Medical Sciences
Outcome results
None listed