Minor recurrent aphthous stomatitis. Recurrent oral aphthae
Conditions
Interventions
Intervention 1: Intervention group: The intervention group will receive oral allicin tablets (400 mg, Dineh, Iran) containing 1100 micrograms of allicin. The patient will take 4 allicin tablets daily
4 time a day (every 6 hours) for 10 days.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Patients with minor recurrent aphthous stomatitis Men and women aged 18 to 50 who are able to follow a doctor's advice Willing to participate in the study and not use painkillers during it Patients with aphthous lesions on the lips, buccal mucosa, floor of the mouth, and tongue Has an aphthous ulcer (up to 48 hours have passed since the lesion formed) smaller than 10 mm
Exclusion criteria
Exclusion criteria: History of allergy to allicin Pregnancy or breastfeeding Ulcers as a manifestation of a systemic disease such as Behçet's disease, ulcerative colitis, Crohn's disease, or acquired immunodeficiency Use of nonsteroidal anti-inflammatory drugs, narcotics, immunomodulating agents, systemic antibiotics in the 2 weeks prior to study entry Treatment with any topical or oral medication within 1 month prior to study entry Invasive dental procedure within 2 weeks prior to study entry A patient who uses toothpaste containing anti-inflammatory drugs The patient has a bleeding disorder.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The distance between the 2 outer edges of the ulcer border in mm; lesions less than 1 mm in diameter will be considered healed. Timepoint: Day of referral (start of use), third, seventh, and tenth after starting use. Method of measurement: To determine the wound size, the researcher measures the distance between the 2 outer edges of the wound border in millimeters using a calibrated dental probe (D&G, Pakistan).;Patients are taught to determine the intensity of their pain based on a visual analogue scale. Patients will record their pain in a checklist 3 times a day after each meal and lesions with a pain value of 1 cm or less will be considered healed. Timepoint: Day of referral (start of use), third, seventh, and tenth after starting use. Method of measurement: Using a visual analog scale; in which the patient marks their pain level from 0 to 10 on a 10-centimeter line on the day of the visit, third, seventh, and tenth day.;Healing period. Timepoint: Day of referral (start of use), third, seventh, and tenth after starting use. Method of measurement: If both the pain level on the visual analog scale is 1 cm or less and the lesion size is 1 mm or less, the lesion is considered healed. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBehrouz Todarvari
Mazandaran University of Medical Sciences
Outcome results
None listed