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Determining the effect of topical Gabapentin ointment on neuropathic pain.

Investigating the effect of topical Gabapentin ointment on peripheral neuropathic pain in cancer patients treated with Oxaliplatin.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241207063969N1
Enrollment
116
Registered
2025-03-26
Start date
2025-01-19
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neuropathic pains caused by cancer. Other specified diabetes mellitus with diabetic neuropathic arthropathy

Interventions

Intervention 1: Intervention group: Patients in this group will apply 10% gabapentin gel as a base cream (liposomal) to the pain site. They will be asked to clean the painful area and then massage 4 m

Sponsors

Sabzevar University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: People aged between 18 and 75 years. Cancer patients undergoing the first course of Oxaliplatin treatment.

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding. Patients with diabetic (type 1 and type 2 diabetic patients) neuropathy and trauma. Abuse of alcohol, drugs, and smoking. Taking painkillers routinely starting two weeks before beginning Gabapentin. History of chemotherapy with Taxane group drugs, including Paclitaxel (Taxol) and Docetaxel (Taxotere). Previous history of chemotherapy with Oxaliplatin drug. History of sensitivity to Gabapentin. People who have experienced neuropathic pain due to the same cancer before taking the drug.

Design outcomes

Primary

MeasureTime frame
Neuropathic pain. Timepoint: At the beginning of the study (before the start of the intervention), 14, 21, 35 days after starting the use of topical gabapentin. Method of measurement: Visual Analogue Scale (VAS) to assess patients' pain severity.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammad Sahebkar

Sabzevar University of Medical Sciences

mohammad.sahebkar66@yahoo.com+98 51 4401 8300

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026