Socket Preservation with Collagen and Its Impact on Post-Extraction Healing

Clinical Evaluation of the Impact of Socket Preservation Using Collagen-Based Clot Retention Compared to Conventional Methods on Wound Healing Following Tooth Extraction in Patients Requiring Tooth Extraction

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241204063947N1

Enrollment

Registered

2025-02-04

Start date

2017-07-23

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atraumatic tooth extraction, soft tissue healing.

Interventions

Intervention 1: Intervention group: The tooth extraction was performed conservatively and bilaterally. On one side, the dental socket was managed using natural collagen (Collacone, Botiss Biomaterials

Daroupakhsh, Tehran, Iran), the periodontal ligaments were separated using a periosteal elevator, and the tooth was extracted conservatively using universal forceps (Aesculap Co, USA) with vertical an

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Healthy people without systemic diseases Adults aged 18 to 65 years Patients undergoing simple tooth extraction Patients who are candidates for extraction of bilateral premolars for orthodontic treatment Patients who provided full and informed consent to participate in the study

Exclusion criteria

Exclusion criteria: People who are prohibited from performing dental procedures History of allergy to collagen or related substances Presence of active oral infections Using immunosuppressive drugs or antibiotics Smoking

Design outcomes

Primary

Measure	Time frame
Soft tissue healing. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Wound closure and presence of any signs of infection or inflammation.	—

Secondary

Measure	Time frame
Pain level. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Visual Analogue Scale.;Infection rate. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Clinical evaluation for signs of infection such as redness, swelling, pus, or increased pain at the extraction site.;Patient satisfaction. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: 5-point Likert scale, where 1 is "very dissatisfied" and 5 is "very satisfied.".;Swelling. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Visual Analogue Scale.	—

Measure

Time frame

Pain level. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Visual Analogue Scale.;Infection rate. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Clinical evaluation for signs of infection such as redness, swelling, pus, or increased pain at the extraction site.;Patient satisfaction. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: 5-point Likert scale, where 1 is "very dissatisfied" and 5 is "very satisfied.".;Swelling. Timepoint: At baseline (immediately post-extraction), and at 14 and 28 days after the procedure. Method of measurement: Visual Analogue Scale.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Bakhtiari

Shahid Beheshti University of Medical Sciences

zeinabbakhtiari@sbmu.ac.ir+98 21 23871

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026