The effect of chewing gum containing pomegranate peel extract and green tea on oral bacteria and dental plaque

Determining the effect of chewing gum containing pomegranate peel extract and green tea on the amount of Streptococcus mutans in saliva, pH of saliva and plaque index

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241204063938N1

Enrollment

Registered

2025-01-23

Start date

2025-02-19

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: The amount of Streptococcus mutans in saliva. Condition 2: The amount of pH of saliva. Condition 3: The amount of plaque index.

Interventions

Intervention 1: Intervention group: Consumer group of the combination of pomegranate peel extract and green tea (use of gum base plus plant). Intervention 2: Control group: placebo recipient (use of g

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Participants do not have systemic disease Have acceptable oral hygiene (no obvious plaque and tartar). Age range from 18 to 65 years. Having a grade 2 index plate

Exclusion criteria

Exclusion criteria: Thay dont have proper cooperation. Participants have systemic disease.

Design outcomes

Primary

Measure	Time frame
Plaque index. Timepoint: It is at the beginning of the study (before the start of the study) and on the 14th day after the start of chewing gum. Method of measurement: Plaque index is calculated using O Leary index.	—

Secondary

Measure	Time frame
Ph salivary. Timepoint: It is at the beginning of the study (before the start of the study) and on the 14th day after the start of chewing gum. Method of measurement: It is done using a pH meter electrode.;Streptococcus mutans in saliva. Timepoint: It is at the beginning of the study (before the start of the study) and on the 14th day after the start of chewing gum. Method of measurement: Saliva samples are sent to the microbiology laboratory to determine the number of Streptococcus mutans colonies, and they are cultured and counted in the special Mitis salivarius agar medium at 37°C.	—

Measure

Time frame

Ph salivary. Timepoint: It is at the beginning of the study (before the start of the study) and on the 14th day after the start of chewing gum. Method of measurement: It is done using a pH meter electrode.;Streptococcus mutans in saliva. Timepoint: It is at the beginning of the study (before the start of the study) and on the 14th day after the start of chewing gum. Method of measurement: Saliva samples are sent to the microbiology laboratory to determine the number of Streptococcus mutans colonies, and they are cultured and counted in the special Mitis salivarius agar medium at 37°C.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Hosseinpour Sarmadi

Tabriz University of Medical Sciences

Hosseinpoursarmadi@tbzmed.ac.ir+98 41 3336 3298

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026