Investigation of Neurotransmitter Alteration Pre and Post Induction of Transcranial Random Noise Electrical Stimulation (tRNS) in Decompensated Tinnitus Subjects

Investigation of Neurotransmitter Alteration Using Magnetic Resonance Spectroscopy (MRS) based on the Findings of Functional Magnetic Resonance Imaging (fMRI) Pre and Post Induction of Transcranial Random Noise Electrical Stimulation (tRNS) in Decompensated Tinnitus Subjects

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241203063931N1

Enrollment

Registered

2025-01-20

Start date

2025-02-19

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The patients with unilateral tonal decompensated tinnitus based on THI and TQ questionnaires. Tinnitus

Interventions

Intervention 1: Intervention group 1: Measurement of neurotransmitters in adults with unilateral tinnitus at designated areas by fMRI using MRS, before and after electrical stimulant and after 7 tRNS

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adults with unilateral tonal tinnitus Decompensated tinnitus (according to THI and TQ questionnaires) Patients with confirmed mental and cognitive health by a psychiatrist

Exclusion criteria

Exclusion criteria: Individuals with known diseases or psychiatric illnesses Pregnant patients

Design outcomes

Primary

Measure	Time frame
Type and changes of neurotransmitters in patients with unilateral decompensated tonal tinnitus based on the THI and TQ questionnaire, pre and post acute stimulus, pre and post induction of 7 tRNS sessions. Timepoint: Investigation of neurobiochemical metabolic biomarkers of the brain at the beginning of the study (before the intervention), In the same session after the stimulant or placebo and also after 7 sessions of intervention measures using the tRNS. Method of measurement: Measuring biomarkers at designated parts in the brain by fMRI using the MRS method.	—

Measure

Time frame

Type and changes of neurotransmitters in patients with unilateral decompensated tonal tinnitus based on the THI and TQ questionnaire, pre and post acute stimulus, pre and post induction of 7 tRNS sessions. Timepoint: Investigation of neurobiochemical metabolic biomarkers of the brain at the beginning of the study (before the intervention), In the same session after the stimulant or placebo and also after 7 sessions of intervention measures using the tRNS. Method of measurement: Measuring biomarkers at designated parts in the brain by fMRI using the MRS method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoume Avateffazeli

Iran University of Medical Sciences

masoumeavatef.fazeli@gmail.com+98 21 6650 4294

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026