Drug-induced acute kidney injury. Acute kidney failure, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will receive intravenous vancomycin along with injectable N-Acetylcycteine. Vancomycin will be administered with a loading dose o
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years old Receiving vancomycin for at least 5 days Baseline serum creatinine clearance above 30 ml/min at the start of treatment Hospitalized in infectious diseases ward of Shahid Sadoughi Hospital of Yazd Informed consent to participate in the study
Exclusion criteria
Exclusion criteria: History of hypersensitivity to Vancomycin and injectable N-Acetylcyteine Concurrent use of nephrotoxic drugs. Including amphotericin B, aminoglycosides contrast media and NSAIDs Concurrent use of other antioxidants including vitamin C, vitamin E and N-acetylcyctein Body mass index greater than or equal to 3 Receipt of vancomycin within the past 20 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean serum creatinine level. Timepoint: In the present study, serum creatinine, serum urea, and creatinine clearance are measured at baseline (before the intervention) and on days 2, 3, 4, and 5 after the intervention. Method of measurement: autoanalyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in GFR. Timepoint: Daily from study initiation up to 10 days. Method of measurement: Cockcroft-Gault formula.;Incidence of acute kidney injury. Timepoint: Daily assessment using RIFLE criteria until study completion. Method of measurement: Assessment using RIFLE criteria(Risk, Injury, Failure, Loss, End-stage kidney disease).;Drug adverse effects;. Timepoint: Daily from study initiation up to 10 days. Method of measurement: Assessment using Narenjo scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehri Kalouti
Yazd University of Medical Sciences
Outcome results
None listed