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Efficacy of dydrogesterone in the treatment of endometrial polyps

Evaluation of efficacy of dydrogesterone in the treatment of endometrial polyps: a single centre, randomized: double-blind controlled pilot study

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241203063928N1
Enrollment
60
Registered
2025-03-06
Start date
2025-02-03
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis. Endometriosis

Interventions

Intervention 1: Intervention group: The intervention group will include 33 patients with endometrial polyps who will receive 20 mg of dydrogesterone daily (10 mg Duphaston® tablet manufactured by ABBO
importer: Behestan Darou Company, twice a day) from day 15 to 24 of the menstrual cycle for 3 months. Intervention 2: Control group: There will be 33 patients with endometrial polyps who will receive

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
19 Years to 49 Years

Inclusion criteria

Inclusion criteria: Full consent to participate in this study Premenstrual women (age between 20 and 50 years) Having one of the following symptoms in transvaginal ultrasound within 10 days after the start of the menstrual period: Typical symptoms of endometrial polyps: Medium to high echo with a regular margin in the uterine cavity b- atypical symptoms of endometrial polyps: Penetrating cyst in endometrial tissue No history of allergy to hormonal drugs intermenstural bleeding Menorrhagia (more than 2 times compared to the normal state)

Exclusion criteria

Exclusion criteria: History of taking progesterone supplements or hormonal medications in the past 6 months Contraindications to the use of progesterones History of surgery or treatment for endometrial lesions in the past 6 months

Design outcomes

Primary

MeasureTime frame
Size, polyp size, and endometrial thickness. Timepoint: Endometrial polyp changes will be evaluated before and 3 months after the intervention. Method of measurement: The size, shape, and thickness of the endometrium will be assessed based on ultrasound findings.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactEnsie Rezaee

Shahid Beheshti University of Medical Sciences

d.e.rezaee1990@gmail.com+98 21 7343 3000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026