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Cyproheptadin in cystic fibrosis

The Effect of Cyproheptadine on Growth, Respiratory Status, and Quality of Life in Cystic Fibrosis Patients Aged 6–18 Years

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241203063927N1
Enrollment
30
Registered
2025-09-10
Start date
2025-09-23
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cystic fibrosis. E84

Interventions

Intervention group: participants received cyproheptadineTehran daro company (0.25 mg/kg, divided q12h) for six months.

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 18 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria were CF diagnosis confirmed via sweat test or genetic testing age 6–18 years and regardless of pancreatic insufficiency or disease severity.

Exclusion criteria

Exclusion criteria: known cyproheptadine allergy concurrent CNS depressant medication use

Design outcomes

Primary

MeasureTime frame
Amount of weight gain. Timepoint: Before and after 6 months of use of cyproheptadin. Method of measurement: Scales for weight.

Secondary

MeasureTime frame
Height increase rate. Timepoint: Before and after 6 months of use of cyproheptadin. Method of measurement: meters for height.;Improve respiratory condition. Timepoint: Before and after 6 months of use of cyproheptadin. Method of measurement: Spirometery.;Quality of life. Timepoint: Before and after 6 months of use of cyproheptadin. Method of measurement: Quality of life questionnaire for cystic fibrosis patients.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMarzieh azizian

Esfahan University of Medical Sciences

marziehazizian969@gmail.com+98 913 687 3189

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026