Investigation of the effect of garlic tablet on asthma

Investigation of the effect of garlic tablet (Allium savitum) on clinical manifestations and some oxidative stress and inflammatory markers in asthmatic patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241203063921N1

Enrollment

Registered

2025-01-05

Start date

2024-12-21

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asthma. Asthma

Interventions

Intervention 1: Intervention group: Garlic tablets, 500 mg from the Gol Daru brand, are administered to patients every 12 hours for a duration of 4 weeks. Intervention 2: Control group: The placebo, w

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adult male/female patients (ages 18 to 65 years) Diagnosis of asthma based on GINA guidelines 2014 ACT (Asthma Control Test) score of 5–24 with uncontrolled asthma symptoms No asthma exacerbation in the past 4 weeks Completion of informed consent

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Asthma Control Test (ACT) score. Timepoint: Assessment of the Asthma control test score before the intervention and 4 weeks after the intervention. Method of measurement: Asthma Control Test (ACT) questionnaire.;Serum level of Interleukin 13. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: The serum level of Interleukin 13 is measured using the ELISA kit from MyBioSource, following the kit instructions and the sandwich ELISA method.;Measurement of Superoxide Dismutase Activity. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: This assay is performed using the method of Paolett and colleagues. In this method, the activity of the enzyme superoxide dismutase (SOD) is measured based on its ability to inhibit the oxidation of NAD(P)H. According to this method, the superoxide radical is generated from molecular oxygen in the presence of EDTA, manganese chloride II, and mercaptoethanol (the oxidation of NAD(P)H depends on the availability of the superoxide anion). When SOD is added to the assay mixture, it will prevent nucleotide oxidation. The changes in nucleotide oxidation are measured spectrophotometrically at a wavelength of 340 nm under physiological pH.;Measurement of Malondialdehyde Concentration. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: The concentration of malondialdehyde (MDA) in serum samples is measured following reaction with thiobarbituric acid, and the optical absorption of the resulting red-colored product is determined at 412 nm.;Measurement of total plasma antioxidant capacity by the FRAP method. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: In this method, the plasma's ability to reduce ferric ions (Fe³?) is measured. By reducing ferric ions (Fe³?) to ferrous ions (Fe²?) in an acidic pH and in the presence of TPTZ (Tripyridyl-S-triazine), an Fe-TPTZ complex is form	—

Measure

Time frame

Asthma Control Test (ACT) score. Timepoint: Assessment of the Asthma control test score before the intervention and 4 weeks after the intervention. Method of measurement: Asthma Control Test (ACT) questionnaire.;Serum level of Interleukin 13. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: The serum level of Interleukin 13 is measured using the ELISA kit from MyBioSource, following the kit instructions and the sandwich ELISA method.;Measurement of Superoxide Dismutase Activity. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: This assay is performed using the method of Paolett and colleagues. In this method, the activity of the enzyme superoxide dismutase (SOD) is measured based on its ability to inhibit the oxidation of NAD(P)H. According to this method, the superoxide radical is generated from molecular oxygen in the presence of EDTA, manganese chloride II, and mercaptoethanol (the oxidation of NAD(P)H depends on the availability of the superoxide anion). When SOD is added to the assay mixture, it will prevent nucleotide oxidation. The changes in nucleotide oxidation are measured spectrophotometrically at a wavelength of 340 nm under physiological pH.;Measurement of Malondialdehyde Concentration. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: The concentration of malondialdehyde (MDA) in serum samples is measured following reaction with thiobarbituric acid, and the optical absorption of the resulting red-colored product is determined at 412 nm.;Measurement of total plasma antioxidant capacity by the FRAP method. Timepoint: before the intervention and 4 weeks after the intervention. Method of measurement: In this method, the plasma's ability to reduce ferric ions (Fe³?) is measured. By reducing ferric ions (Fe³?) to ferrous ions (Fe²?) in an acidic pH and in the presence of TPTZ (Tripyridyl-S-triazine), an Fe-TPTZ complex is form

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZohre Rahimipour

Yasouj University of Medical Sciences

zohreh632011@gmail.com+98 74 3322 5187

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026