The effect of intraoperative cerebral oximetry monitoring on neurocognitive disorders after coronary artery bypass surgery

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241202063912N1

Enrollment

102

Registered

2024-12-14

Start date

2025-01-04

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurocognitive disorders after coronary artery bypass surgery. Ischemic heart diseases

Interventions

Intervention 1: Intervention group: In this group, the oximeter is placed on the skin on the forehead of the patients from the beginning of the surgery. rSO2 is continuously monitored during surgery.

Eligibility

Sex/Gender

All

Age

50 Years to 75 Years

Inclusion criteria

Inclusion criteria: All patients aged 50 to 75 who are candidates for coronary artery bypass surgery without the use of a cardiopulmonary pump and who have given written consent to participate in the study.

Exclusion criteria

Exclusion criteria: Lack of patient consent to participate in the study History of neuropsychiatric diseases History of taking neuropsychiatric drugs History of concussion Emergency CABG candidate patients History of schizophrenia disease, Parkinson's disease, epilepsy myasthenia gravis or severe dementia (Severe cognitive dysfunction based on score of Mini-Mental State Examination < 24 points) Addiction to psychoactive drugs and alcohol All patients who undergo on-pump coronary artery bypass surgery History of cardiovascular surgery History of neurosurgery History of CVA

Design outcomes

Primary

Measure	Time frame
Occurrence of cognitive impairment based on Confusion Assessment Method for the Intensive Care Unit. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Using Confusion Assessment Method for the Intensive Care Unit.;Occurrence of stroke. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Computed tomography.;Occurrence of convulsions. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Electroencephalography.;Occurrence of paresis. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Electroneuronography and electromyography.;Occurrence of paralysis. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Physical examination and medical imaging.	—

Measure

Time frame

Occurrence of cognitive impairment based on Confusion Assessment Method for the Intensive Care Unit. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Using Confusion Assessment Method for the Intensive Care Unit.;Occurrence of stroke. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Computed tomography.;Occurrence of convulsions. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Electroencephalography.;Occurrence of paresis. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Electroneuronography and electromyography.;Occurrence of paralysis. Timepoint: After the surgery every day until three days after surgery. Method of measurement: Physical examination and medical imaging.

—

Secondary

Measure	Time frame
Sedative state. Timepoint: After surgery and extubation. Method of measurement: Richmond Agitation-Sedation Scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmeneh Zarebidoki

Yazd University of Medical Sciences

a.zarebidoki@stu.ssu.ac.ir??+98 35 3825 9682

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026