Knee osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group: One injection of platelet-rich plasma. Intervention 2: Intervention group: Three injections of platelet-rich plasma at one-week intervals.
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: All patients aged 40 to 75 years, regardless of gender, with knee pain (for at least 3 months) and radiological staging according to the Kellgren-Lawrence (KL) system of grades 1, 2, and 3.
Exclusion criteria
Exclusion criteria: KL Grade 4 BMI above 35 Hemoglobin level below 10 Use of medication, physiotherapy, and exercise therapy during the intervention Use of nonsteroidal anti-inflammatory drugs (NSAIDs) and systemic steroids or immunomodulators within the last week and three months after PRP injection Malignancies and poor general condition Use of anticoagulant drugs History of infection/steroid injection/arthroscopy/knee surgery Concomitant back pain Thrombocytopenia Bleeding disorders Knee inflammation and effusion fluid accumulation Osteoarthritis secondary to inflammatory/metabolic diseases Knee instability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain score. Timepoint: At the beginning of the study and 3 and 6 months after injection. Method of measurement: Visual Analogue Scale.;Performance. Timepoint: At the beginning of the study and 3 and 6 months after injection. Method of measurement: WOMAC questionaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Articular cartilage thickness. Timepoint: At the beginning of the study and 6 months after injection. Method of measurement: Ultrasound machine. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHajar Salimi
Mazandaran University of Medical Sciences
Outcome results
None listed