Fatigue in multiple sclerosis. Multiple sclerosis
Conditions
Interventions
Intervention 1: Intervention group: For patients, the drug Lysdexamfetamine dimesylate is initially started at a dose of 30 mg daily, and then, if the patient tolerates it, it is increased by 20 mg ev
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adults with multiple sclerosis according to the McNeeshan 2017 criteria EDSS less than 5.5 MIFS>33 according to the Fatigue criterion.
Exclusion criteria
Exclusion criteria: Severe depression Hypothyroidism Severe anemia (Hb‹ 9 g/dl) Breastfeeding or pregnancy History of ischemic cerebrovascular accident or cardiovascular disease Decreased kidney function Presence of an MS attack within the past month Uncontrolled blood pressure (blood pressure = 160/100 mm Hg) Concomitant use of medications that affect fatigue History of drug, psychotropic, and alcohol abuse Concomitant use of monoamine oxidase inhibitors and serotonin reuptake inhibitors Presence of narcolepsy The presence of psychosis History of seizures History of vascular disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fatigue. Timepoint: Beginning of study, weeks 4, 6, 8. Method of measurement: Kurtzke Functional Systems Scores) MSFC,FSS( ? PSQI? MFI?SF-36 ? Fatigue Severity Scale (FSS) of Sleep Disorders ? HADS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyad Mohammad Baghbanian
Mazandaran University of Medical Sciences
Outcome results
None listed