Effect of Oral Caffeine on Fatigue in Multiple Sclerosis Patients

The Effects of Oral Caffeine on Fatigue in Multiple Sclerosis Patients: A Randomized Double Blind Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241129063892N1

Enrollment

Registered

2024-12-08

Start date

2024-12-14

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatigue in multiple sclerosis.

Interventions

Intervention 1: Intervention group: Administration of 200 mg caffeine tablets (manufactured by Eurho Vital),at a dose of half a tablet (equivalent to 100 mg) once a day, for a duration of three months

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients aged 18 years and older diagnosed with multiple sclerosis Obtaining informed consent. Having a fatigue score (MFIS) greater than 33.

Exclusion criteria

Exclusion criteria: Diagnosis of depression Anemia Hypothyroidism Hypertension Cardiac arrhythmias Caffeine sensitivity Concurrent use of medications affecting fatigue Lack of consent to participate or continue in the study Irregular medication use or non-adherence to the study schedule History of using medications containing caffeine. Pregnancy Recent caffeine consumption within the past week.

Design outcomes

Primary

Measure	Time frame
Fatigue score in the Modified Fatigue Impact Scale (MFIS) questionnaire. Timepoint: At the beginning of the study and three months after caffeine consumption. Method of measurement: Modified Fatigue Impact Scale questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAida gharanjig

Mazandaran University of Medical Sciences

A.gharanjik93@gmail.com+98 911 424 9771

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026