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Comparative Effect of Ketamine and Electroconvulsive Therapy on Suicidal Ideation

Comparative Effect of Ketamine and Electroconvulsive Therapy on Suicidal Ideation in Patients with Major Depressive Disorder

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241129063888N1
Enrollment
28
Registered
2025-09-14
Start date
2025-09-23
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major depression. Major depressive disorder, single episode

Interventions

Intervention 1: Intervention group: The first intervention group consists of people with major depression and suicidal thoughts who are treated with 6 sessions of electroconvulsive therapy. Interventi

Sponsors

Zanjan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Having major depressive disorder according to diagnostic criteria (DSM-V) with suicidal thoughts Patients over 18 years of age of both sexes Consent to participate in the study

Exclusion criteria

Exclusion criteria: Patients with bipolar disorder Co-existing psychiatric illness other than major depressive disorder History of substance use in the last 3 months History of significant side effects related to anesthetic drugs History of cardiovascular disease Patients with body implants such as pacemakers, intracranial electrodes, etc Pregnant women Presence of contraindications to ECT such as brain space-occupying lesions, high ICP, and recent myocardial infarction Unwillingness to participate in the study History of high blood pressure, cardiac conduction disorders, and tachycardia

Design outcomes

Primary

MeasureTime frame
Depression score on the Montgomery Inventory. Timepoint: Determination of depression score with Montgomery test at the beginning of the study after the end of the interventions and one month after the end of the interventions. Method of measurement: Montgomery Depression Questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHanieh Zhalemehrabi

Zanjan University of Medical Sciences

honeyzhale@gmail.com+98 24 3354 4001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026