Drug-induced acute kidney injury. Acute kidney failure, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Patients in the intervention group will receive intravenous vancomycin along with oral melatonin. Vancomycin will be administered with a loading dose of 20 mg/kg ba
Sponsors
Yazd University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age over 18 years old Receiving vancomycin for at least 4 days Baseline serum creatinine clearance above 30 mL/min at the start of treatment Hospitalized in infectious diseases ward of Shahid Sadoughi Hospital of Yazd Informed consent to participate in the study
Exclusion criteria
Exclusion criteria: History of hypersensitivity to vancomycin or melatonin Concurrent use of nephrotoxic drugs including amphotericin B, aminoglycosides, contrast media and NSAIDs Concurrent use of other antioxidants including vitamin C, vitamin E and N-acetylcysteine Body mass index greater than or equal to 30 Receipt of vancomycin within the past 20 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean serum creatinine level. Timepoint: Day 1 (baseline), Day 2, Day 3, Day 4, Day 5. Method of measurement: autoanalyzer. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in GFR. Timepoint: Daily from study initiation up to 14 days. Method of measurement: Cockcroft-Gault formula.;Incidence of acute kidney injury. Timepoint: Daily assessment using RIFLE criteria until study completion. Method of measurement: Assessment using RIFLE criteria (Risk, Injury, Failure, Loss, End-stage kidney disease).;Drug adverse effects:. Timepoint: Daily from study initiation up to 14 days. Method of measurement: Assessment using Naranjo scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Amin Salehi Abarqoui
Yazd University of Medical Sciences
Outcome results
None listed