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Comparison of typical and atypical antipsychotics in Schizophrenia patients and their side effects

Comparison of typical and atypical available antipsychotics for the treatment of aggression and evaluation of their side effects in schizophrenic patient referred to the Ahvaz Golestan Hospital.

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241122063800N1
Enrollment
80
Registered
2024-12-16
Start date
2025-04-05
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Schizophrenia

Interventions

Intervention 1: The intervention groups include two groups. "First intervention group": 40 schizophrenic patients with aggression selected by randomization method who receive typical antipsychotic med

Sponsors

Research Vice-Chancellor of Jundishapur University of Medical Sciences, Ahvaz
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Schizophrenic patients based on DSM-5 and confirmed by a psychiatrist Having an episode of physical assault on another person during hospitalization Aggression, which is evident in the presence of another aggressive event, either physical or verbal or against property

Exclusion criteria

Exclusion criteria: patients with bipolar disorder, personality disorder and schizoaffective disorder, drug addiction Pregnant or lactating mothers Patients with uncontrolled medical conditions such as diabetes and high blood pressure Patients with severe cognitive disease, severe organic brain disease, or severe mental retardation Lack of cooperation in regular drug use during the study period Change of target drugs for any reason to non-study drugs during the study period Hospitalization for more than one year Use of long-acting injectable antipsychotics within thirty days before randomization

Design outcomes

Primary

MeasureTime frame
Effectiveness and side effects of drugs in schizophrenia patients. Timepoint: Before starting the drug, 24 and 48 hours after taking the drug, 1 week, 2 weeks, 4 weeks, 6 weeks after taking the drug. Method of measurement: Modified Overt Aggression Scale (MOAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoume Nazari Nesab

Ahvaz University of Medical Sciences

nazarinasab-m@ajums.ir+98 61 3374 3001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026