Rectal cancer. Malignant neoplasm of rectum
Conditions
Interventions
Intervention 1: Intervention Group 1: A single intravenous dose of 8 mg dexamethasone administered during anesthesia induction. The dexamethasone ampoule (8 mg in 2 mL) is manufactured by Osveh Pharma
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age between 18 - 80 Positive rectal cancer pathology Elective therapeutic surgery Obtaining informed consent
Exclusion criteria
Exclusion criteria: Steroid use contraindication On long-term corticosteroid therapy The American Society of Anesthesiologists (ASA) Physical Status Classification score greater than 3
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-Reactive Protein. Timepoint: One day before, and on days three and five after the intervention. Method of measurement: Latex agglutination test.;Interleukin 6. Timepoint: One day before, and on days three and five after the intervention. Method of measurement: ELISA. | — |
Secondary
| Measure | Time frame |
|---|---|
| 3-year overall survival rate. Timepoint: Three years after the intervention. Method of measurement: Ask the individual, or the family in case of death.;Relapse. Timepoint: Three years after the intervention. Method of measurement: Ask the individual, or the family in case of death.;Quality of life. Timepoint: One day before, and 30 days after the intervention. Method of measurement: European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire.;Post-operative complications index. Timepoint: 30 days after the intervention. Method of measurement: Checklist of Clavien Dindo Grade.;Post-operative complications index. Timepoint: 30 days after the intervention. Method of measurement: Comprehensive Complication Index Calculator.;Time to first passage of stool. Timepoint: 30 days after the intervention. Method of measurement: History taking.;Nausea. Timepoint: 30 days after the intervention. Method of measurement: History taking.;Vomiting. Timepoint: 30 days after the intervention. Method of measurement: History taking.;Surgical site infection. Timepoint: 30 days after the intervention. Method of measurement: History taking and examination.;Small bowel obstruction. Timepoint: 30 days after the intervention. Method of measurement: History taking and examination.;Pleural effusion. Timepoint: 30 days after the intervention. Method of measurement: History taking and examination and radiography.;Anastomotic leak. Timepoint: 30 days after the intervention. Method of measurement: History taking and examination and radiography.;Urinary tract infection. Timepoint: 30 days after the intervention. Method of measurement: History taking and urine culture.;Anemia. Timepoint: 30 days after the intervention. Method of measurement: Complete blood count.;Atelectasis. Timepoint: 30 days after the intervention. Method of measurement: History taking and chest X-Ray.;Length of hospital stay. Timepoint: 30 days after the intervention. Method of measurement: Patient's re | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAtieh Mahmoudi
Iran University of Medical Sciences
Outcome results
None listed