Effect of Dapagliflozin on the occurrence of Atrial fibrillation rhythm

Studying the effect of Dapagliflozin on the occurrence of Atrial fibrillation rhythm after coronary artery bypass graft surgery in a clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241121063794N1

Enrollment

Registered

2025-04-08

Start date

2025-04-21

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post operative Atrial fibrilation.

Interventions

Intervention 1: "Intervention group:" Dapagliflozin recipients who underwent echocardiography during hospitalization and were treated with dapagliflozin 10 mg (Medava Pharmaceutical Company) daily for

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients over 18 years Patients who have given informed consent Sinus rhythm before surgery

Exclusion criteria

Exclusion criteria: History of diabete Need for emergency CABG Contraindication for dapagliflozin History of SGLT2in use before hospitalization History of thyroid problem Need for simultaneous valve surgery Previous history of heart surgery History of congenital heart disease History of atrial fibrillation rhythm before hospitalization History of pacemaker implantation

Design outcomes

Primary

Measure	Time frame
Post-operative atrial fibrillation (POAF) is one of the most important complications of cardiac surgery, which can increase morbidity and mortality, increase length of stay, and cost of treatment, and can also lead to dangerous consequences such as heart attack, acute renal infarction, congestive heart failure, and even death for the patient. Timepoint: To assess AF rhythm, patients are monitored 24 hours a day in the cardiac surgery intensive care unit with 24-hour monitoring, on the second day in the ward with ECG every 8 hours or when the patient becomes symptomatic and ECG is taken on the third day with 24-hour Holter monitoring (given the maximum incidence of AF on the third day), and on the fourth day with ECG. Method of measurement: Holter heart rhythm Electrocardiogram.	—

Measure

Time frame

Post-operative atrial fibrillation (POAF) is one of the most important complications of cardiac surgery, which can increase morbidity and mortality, increase length of stay, and cost of treatment, and can also lead to dangerous consequences such as heart attack, acute renal infarction, congestive heart failure, and even death for the patient. Timepoint: To assess AF rhythm, patients are monitored 24 hours a day in the cardiac surgery intensive care unit with 24-hour monitoring, on the second day in the ward with ECG every 8 hours or when the patient becomes symptomatic and ECG is taken on the third day with 24-hour Holter monitoring (given the maximum incidence of AF on the third day), and on the fourth day with ECG. Method of measurement: Holter heart rhythm Electrocardiogram.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamid Nobakht

Tehran University of Medical Sciences

Hamid79.hn@gmail.com+98 937 184 6437

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026