Effect of intravenous administration of magnesium sulfate on the procedural pain in patients undergoing coronary angiography

Effect of intravenous administration of magnesium sulfate on the intra- and post-procedural pain in patients undergoing transradial coronary angiography: A randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241113063693N1

Enrollment

Registered

2024-12-14

Start date

2024-12-05

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Procedural pain. Condition 2: Radial artery spasm. Condition 3: Coronary angiography. Other acute postprocedural pain

Interventions

Intervention 1: Intervention group: Patients are given magnesium sulfate at a dose of 30 mg/kg in 100 cc of normal saline solution intravenously within 20 minutes before the procedure begins. Interven

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients undergoing transradial coronary angiography Age over 18 years old The ability to express pain in the patient

Exclusion criteria

Exclusion criteria: Contraindications for taking magnesium sulfate Known renal, hepatic, or cardiac failure History of heart block Known neuromuscular diseases Pregnancy and breastfeeding History of previous treatment with opioid medications or calcium channel blockers History of alcohol or opioid abuse

Design outcomes

Primary

Measure	Time frame
Pain intensity in the intervention site during and after coronary angiography. Timepoint: During angiography and then 1, 2, and 4 hours after angiography. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Radial artery spasm. Timepoint: During angiography. Method of measurement: Clinical diagnosis by interventional cardiologist.;The amount of need for opioid analgesics. Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: A dose of medication prescribed to a patient to provide pain relief and recorded in the hospitalization record.;Hypotension (systolic blood pressure below 90 mmHg). Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: Monitoring with a blood pressure cuff.;Bradycardia (heart rate below 50 beats per minute). Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: Monitoring with pulse oximeter.;Nausea and vomiting. Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: Questionnaire and observation.	—

Measure

Time frame

Radial artery spasm. Timepoint: During angiography. Method of measurement: Clinical diagnosis by interventional cardiologist.;The amount of need for opioid analgesics. Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: A dose of medication prescribed to a patient to provide pain relief and recorded in the hospitalization record.;Hypotension (systolic blood pressure below 90 mmHg). Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: Monitoring with a blood pressure cuff.;Bradycardia (heart rate below 50 beats per minute). Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: Monitoring with pulse oximeter.;Nausea and vomiting. Timepoint: During angiography and then until the patient is hospitalized. Method of measurement: Questionnaire and observation.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmadreza Sadeghi

Karaj University of Medical Sciences

ahmadrezasadeghiars@gmail.com+98 21 6554 3581

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026