Investigating the effect of L-carnitine on the improvement of fatigue in cancer patients

Investigating the effect of L-carnitine on the improvement of fatigue in cancer patients receiving platinum-based chemotherapy regimens: a clinical trial study

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241112063688N1

Enrollment

Registered

2024-11-28

Start date

2024-12-05

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancers treated with platinum-based chemotherapy regimens. Personal history of malignant neoplasm

Interventions

Intervention 1: L-carnitine group: patients will be randomly divided into two groups by block method and then one group will be treated with one gram of liquid L-carnitine solution twice a day for 4 w

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 18 years or older Platinum based chemotherapy regimen Patients with a score of 0 to 3 with the functional level status assessment scale

Exclusion criteria

Exclusion criteria: Prevoius usage of Carnitone History of seizure Presense of brain metastasis Kidney failure Liver failure Respiratory failure

Design outcomes

Primary

Measure	Time frame
Evaluation of average fatigue from BFI (Brief fatigue inventory) questionnaire. Timepoint: From the beginning of the study to the fourth week. Method of measurement: BFI (Brief fatigue inventory) questionnaire.	—

Secondary

Measure	Time frame
State of mind. Timepoint: At the beginning of the study as the base scale and week four and week eight. Method of measurement: The BFI questionnaire is a 9-part scale that has been validated to assess the severity of fatigue and its effect on the function of patients with cancer.;Evaluating the pain. Timepoint: At the beginning of the study as the base scale and week four and week eight. Method of measurement: The BPI questionnaire, a valid scale for pain assessment, will be examined in the form of four items to assess the intensity of pain, which will evaluate the score from 0 to 10 to assess the intensity of pain in these patients.;Investigating mental disorders including depression. Timepoint: At the beginning of the study as the base scale and week four and week eight. Method of measurement: The Center for Epidemiological Studies Depression Scale (CES-D) is a 20-item scale (range 0 to 60) that was used to assess depression. Scores greater than 16 indicate a potentially significant level of depression.	—

Measure

Time frame

State of mind. Timepoint: At the beginning of the study as the base scale and week four and week eight. Method of measurement: The BFI questionnaire is a 9-part scale that has been validated to assess the severity of fatigue and its effect on the function of patients with cancer.;Evaluating the pain. Timepoint: At the beginning of the study as the base scale and week four and week eight. Method of measurement: The BPI questionnaire, a valid scale for pain assessment, will be examined in the form of four items to assess the intensity of pain, which will evaluate the score from 0 to 10 to assess the intensity of pain in these patients.;Investigating mental disorders including depression. Timepoint: At the beginning of the study as the base scale and week four and week eight. Method of measurement: The Center for Epidemiological Studies Depression Scale (CES-D) is a 20-item scale (range 0 to 60) that was used to assess depression. Scores greater than 16 indicate a potentially significant level of depression.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Parsa

Shahid Beheshti University of Medical Sciences

aliparsa131272@gmail.com+98 21 7343 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026