Signs of Major Depressive Disorder. Major depressive disorder, recurrent
Conditions
Interventions
Intervention 1: Intervention group: After obtaining Informed Consent, they enter the study and in addition to receiving routine treatments for depression, for 8 weeks they are also treated with Naceth
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Completion of Informed Consent by The legal guardian of Patient with Major Depression Disorder Fulfilling the Diagnostic Criteria for Major Depressive Disorder (First episode or recurrent episodes) Score of MADRS = 19 at the time of entering the study Treatment Stability of Patients for at least 2 weeks before Random Selection of Participants Effective use of Contraceptive Methods if women are of Reproductive age or Sexually active
Exclusion criteria
Exclusion criteria: Diagnosis of Bipolar Disorder I or II Primary Clinical Diagnosis of a Personality Disorder Received ECT within the last 6 Months Failure of 3 or more Steps of Adequate Antidepressant Medication Recent Using of more than 500 mg/d of N-acetyl cysteine and 200 µg/d of selenium and 500 IU/d of vitamin E Presence of Systemic Medical Disorder, Including Recent Gastrointestinal Ulcers, Pregnancy or Lactation, Epilepsy, Chronic Asthma Any Previous Allergic Skin Reaction or Anaphylaxis to N-Acetylcysteine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of patient whose score of Montgomery-Asberg Depression Scale (MADRS) is greater than 19. Timepoint: Examining the score of the Montgomery-Asberg Depression Scale (MADRS) before the start of the study and 8 weeks after treatment and 4 weeks after stopping treatment (12 weeks from the start of treatment). Method of measurement: Montgomery-Asberg Depression Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Mirbeygi
Arak University of Medical Sciences
Outcome results
None listed