Skip to content

The effect of end-expiratory pressure of 0 or 5 cmH2O on the amount of pulmonary atelectasis in patients undergoing head and neck surgery

Effect of end-expiratory pressure on the amount of pulmonary atelectasis in patients undergoing head and neck surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241110063661N1
Enrollment
60
Registered
2025-02-03
Start date
2025-02-19
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atelectasis is the reduction or collapse of a part of the lung tissue that reduces ventilation in that area. This condition may be caused by obstruction of the airways (such as accumulation of secretions, foreign object, or tumor) or external pressure on the lung (such as the presence of fluid, air, or tumor in the pleural space). Symptoms include shortness of breath, decreased breathing noise, and hypoxemia. Positive exhalation pressure (PEEP) is an important parameter in the management of mech

Interventions

Intervention group: Intervention groups include patients under anesthesia and ventilation with PEEP=5..

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 70 Years

Inclusion criteria

Inclusion criteria: Adult patients aged 20 to 70 years Adult patients aged 18 to 70 years with physical status I-II according to the American Society of Anesthesiologists (ASA CLASS I-II), who are referred for head and neck surgeries and are to undergo general anesthesia. Absence of cardiovascular disorders, chronic obstructive pulmonary disease (forced expiratory volume in 1 second / vital capacity 60 percent or less), or a history of underlying lung disease. No history of emphysema, pneumothorax, or previous pulmonary bullae. No history of lung resection surgery. Normal intracranial pressure. No need for separate one-lung ventilation during surgery.

Exclusion criteria

Exclusion criteria: Increased intracranial pressure during surgery Need for position change to non-supine during surgery Occurrence of unexpected pulmonary complications during surgery, including pneumothorax, pulmonary embolism, pleural effusion Occurrence of severe atelectasis grade 3 and the need for recruitment maneuver Oxygen saturation below 94% requires medical intervention. Diagnosis of severe primary atelectasis grade 2 and 3 at the first ultrasound Diagnosis of pleural effusion and/or pneumothorax during the first ultrasound Hemodynamic instability that does not respond to initial treatments

Design outcomes

Primary

MeasureTime frame
The incidence of atelactasia, Intensity of atlactasia. Timepoint: 1 minute after the start of mechanical ventilation and at the end of the surgery. Method of measurement: Lung ultrasound and RM strategy ultrasound examination of the lungs.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactLeila Mashhadi

Mashhad University of Medical Sciences

mashhadil@mums.ac.ir+98 51 3180 2168

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026