Patients undergoing coronary artery bypass surgery. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, 500 micrograms of selenium will be injected in the Del Nido Cardioplegia solution. During surgery, moderate hypothermia (32-34°C) will be
Sponsors
Rajaee heart center
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1- The patient's willingness to participate in the study Informed consent to participate in the study 3- Age 18 to 75 years old 4- Left ventricular ejection fraction greater than 30% 5- No history of sternotomy and previous cardiac surgeries 5- No history of liver disease, kidney, lung 6- not having valvular problems that require surgery at the same time as coronary arteries 7- not having a pacemaker 8- not being pregnant 9- not having a history of allergy to Selenium 10 - not having G6PD disease -
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1- pump time more than 120 minutes 2- cross-clamp more than 100 minutes 3- performing ultrafiltration technique 4- return of the patient to the cardiopulmonary machine for any reason during
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction. Timepoint: Before operation, after operation and during discharge in control group and selenium group in CABG patients undergoing cardiopulmonary bypass. Method of measurement: Information collection form.;Hemodynamic parameters (vital signs, time to reach the first reversible rhythm, first reversible rhythm, need for inotrope, use of shock or pacemaker, etc.) and arterial blood gas parameters (arterial blood oxygen, pao2, paco2. Timepoint: before induction of anesthesia, after cardioplegia injection, during rewarming, after the end of cardiopulmonary bypass, when entering the ICU, 12 and 24 hours after the operation in the control group and the selenium group in CABG patients undergoing cardiopulmonary bypass. Method of measurement: Data collection form - blood sample.;Biomarkers of myocardial damage (CK-MB, Troponin I. Timepoint: Before the operation, upon entering the ICU and 24 hours after the operation in the control group and the selenium group in CABG patients undergoing cardiopulmonary bypass. Method of measurement: blood sample. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of intubation. Timepoint: Post operative. Method of measurement: patients file.;Length of stay in the intensive care unit. Timepoint: Post operative. Method of measurement: patients file.;Length of stay in the hospital. Timepoint: Post operative. Method of measurement: patients file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactParisa Mohammadghasemi
Rajaee heart center
Outcome results
None listed