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The effect of antiemetic drugs on postoperative nausea and vomiting.

Comparison of the effect of ondansetron, granistron and metoclopramide drugs in preventing nausea and vomiting after colon cancer surgery in Imam Reza Hospital patients in 1403

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241109063644N1
Enrollment
128
Registered
2025-06-08
Start date
2025-05-17
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Postoperative nausea and vomiting. Condition 2: Colon cancer. Other intraoperative and postprocedural complications and disorders of digestive system Malignant neoplasm of colon

Interventions

Intervention 1: Control group: The control group does not receive any medication to prevent nausea and vomiting. Intervention 2: Intervention group: At the beginning of anesthesia, 4 mg (weight under

Sponsors

Artesh University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Obtaining consent to participate in the study Patients undergoing elective surgery Patient with pathology-confirmed colon cancer The patient has undergone total or segmental colectomy.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Postoperative nausea. Timepoint: At 1, 6, 12, 24 and 48 hours after surgery. Method of measurement: visual analog scale (Scoring from zero to ten).;Postoperative vomiting. Timepoint: At 1, 6, 12, 24 and 48 hours after surgery. Method of measurement: Based on the patient's history after surgery (Yes or No).

Secondary

MeasureTime frame
Side effects of medications. Timepoint: At 1, 6, 12, 24 and 48 hours after surgery. Method of measurement: The measurement method is by taking the patient's history and clinical examination after surgery. The reports will be recorded in a checklist.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHosein Khorami

Artesh University of Medical Sciences

hkhorami80@ajaums.ac.ir+98 21 8609 6350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026