Comparison of Dexmedetomidine and Morphine effects for postoperative pain and symptom management following spine surgery

Comparison of Dexmedetomidine and Morphine effects for postoperative pain and symptom management following spine surgery: A randomized clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241108063636N1

Enrollment

Registered

2024-12-15

Start date

2025-01-20

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spondylolisthesis. Spondylolisthesis

Interventions

Intervention 1: Intervention group: Under the prescription of intravenous Dexmedetomidine: Dextosed (Shahid Ghazi pharmaceutical co), initially a bolus dose of 1 microgram per kilogram of patient weig

Eligibility

Sex/Gender

All

Age

15 Years to 65 Years

Inclusion criteria

Inclusion criteria: Individuals undergoing elective spinal surgery at Kowsar Hospital in Semnan."

Exclusion criteria

Exclusion criteria: Neurological and mental disorder addiction heart disease lung disease kidney disease under 15 years over 65 years

Design outcomes

Primary

Measure	Time frame
Intensity of pain. Timepoint: at 6, 12, 24, and 48 hours after the surgery. Method of measurement: Visual Analogue Scale questionnaire consists of a 10-centimeter line, with the two endpoints indicating 0 ("no pain") and 10 ("pain as bad as it can be"). The patient is asked to evaluate their current level of pain by placing a mark on the line.;Request for additional analgesic (Ketorolac). Timepoint: in the first 48 hours after surgery. Method of measurement: Application and Prescription.;Nausea. Timepoint: in the first 48 hours after surgery. Method of measurement: Questionnaire.;Vomiting. Timepoint: in the first 48 hours after surgery. Method of measurement: Occurrence record.;Changes in vital signs. Timepoint: in the first 48 hours after surgery. Method of measurement: Monitoring.;Arrhythmia. Timepoint: in the first 48 hours after surgery. Method of measurement: Monitoring.;Pain from the endotracheal tube. Timepoint: at 6, 12, 24, and 48 hours after the surgery. Method of measurement: Visual Analogue Scale questionnaire consists of a 10-centimeter line, with the two endpoints indicating 0 ("no pain") and 10 ("pain as bad as it can be"). The patient is asked to evaluate their current level of pain by placing a mark on the line.;Ileus. Timepoint: in the first 48 hours after surgery. Method of measurement: Time recording.;Oral tolerance. Timepoint: Time from the end of surgery to the first instance of oral feeding. Method of measurement: Time recording.;Delirium. Timepoint: in the first 48 hours after surgery. Method of measurement: Based on the positive diagnosis of delirium according to the CAM-ICU assessment and the evaluation of four features: (a) acute onset of changes or fluctuations in mental status in the past 24 hours, (b) inattention, (c) disorganized thinking, and (d) altered level of consciousness. Features (a) and (b) are essential for a positive diagnosis of delirium in addition to the presence of either feature (c) or (d). Yes/No (Does delirium exist o	—

Measure

Time frame

Intensity of pain. Timepoint: at 6, 12, 24, and 48 hours after the surgery. Method of measurement: Visual Analogue Scale questionnaire consists of a 10-centimeter line, with the two endpoints indicating 0 ("no pain") and 10 ("pain as bad as it can be"). The patient is asked to evaluate their current level of pain by placing a mark on the line.;Request for additional analgesic (Ketorolac). Timepoint: in the first 48 hours after surgery. Method of measurement: Application and Prescription.;Nausea. Timepoint: in the first 48 hours after surgery. Method of measurement: Questionnaire.;Vomiting. Timepoint: in the first 48 hours after surgery. Method of measurement: Occurrence record.;Changes in vital signs. Timepoint: in the first 48 hours after surgery. Method of measurement: Monitoring.;Arrhythmia. Timepoint: in the first 48 hours after surgery. Method of measurement: Monitoring.;Pain from the endotracheal tube. Timepoint: at 6, 12, 24, and 48 hours after the surgery. Method of measurement: Visual Analogue Scale questionnaire consists of a 10-centimeter line, with the two endpoints indicating 0 ("no pain") and 10 ("pain as bad as it can be"). The patient is asked to evaluate their current level of pain by placing a mark on the line.;Ileus. Timepoint: in the first 48 hours after surgery. Method of measurement: Time recording.;Oral tolerance. Timepoint: Time from the end of surgery to the first instance of oral feeding. Method of measurement: Time recording.;Delirium. Timepoint: in the first 48 hours after surgery. Method of measurement: Based on the positive diagnosis of delirium according to the CAM-ICU assessment and the evaluation of four features: (a) acute onset of changes or fluctuations in mental status in the past 24 hours, (b) inattention, (c) disorganized thinking, and (d) altered level of consciousness. Features (a) and (b) are essential for a positive diagnosis of delirium in addition to the presence of either feature (c) or (d). Yes/No (Does delirium exist o

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Partovian

Semnan University of Medical Sciences

morteza.partovian@gmail.com+98 23 3365 4162

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026