Prophylactic antibiotics: ampicillin and azithromycin versus ampicillin and cefazolin in premature rupture of membranes

Comparison of maternal and neonatal outcomes of two methods of administering prophylactic antibiotics: ampicillin and azithromycin versus ampicillin and cefazolin in premature rupture of membranes

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241107063630N1

Enrollment

Registered

2024-12-17

Start date

2024-12-10

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature rupture of membrane. Premature rupture of membranes

Interventions

Intervention 1: Intervention group: Subjects received a vial of ampicillin antibiotic (Dana Pharmaceutical Company) and a vial of cefazolin antibiotic (Dana Pharmaceutical Company) before cesarean sec

Eligibility

Sex/Gender

Female

Age

15 Years to 40 Years

Inclusion criteria

Inclusion criteria: Informed consent Premature rupture of membrane Ages between 15 and 40

Exclusion criteria

Exclusion criteria: Diabetes Hypertension Lost in follow up

Design outcomes

Primary

Measure	Time frame
Infection. Timepoint: First and second day after intervention. Method of measurement: Fever measurement, history and physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Zeraatpishe

Esfahan University of Medical Sciences

drzeraatpishe.medstudent@gmail.com+98 31 3668 0048

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026