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Investigating the effectiveness of betadine pleurodesis for patients with refractory pleural effusion

Study of the safety and efficacy of pleurodesis with povidone iodine in patients with pleural effusion resistant to treatment with underlying disease

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241106063629N1
Enrollment
67
Registered
2024-12-23
Start date
2025-01-20
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pleural effusion. Pleural effusion, not elsewhere classified

Interventions

Under sterile conditions, 20 cc of betadine is sterile diluted in 80 cc of normal saline and will enter the pleural space using a 50 cc gavage syringe through the catheter and will be clamped for 2 ho

Sponsors

Ghoum University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Recurrent pleural effusion with dyspnea despite treatment of the underlying disease Age above 18 years Absence of infection in other body organs No suspicion of pleural fluid infection Not having a previous history of pleurisy with another substance Life expectancy after pleurodesis is more than one month In cancer patients, at least 2 weeks have passed since chemotherapy

Exclusion criteria

Exclusion criteria: History of anaphylactic reactions to any substance Known thyroid disease Platelets less than 80,000 Infiltration of malignant cells at the catheter site Passing less than a month since the previous pleurodesis on the opposite side

Design outcomes

Primary

MeasureTime frame
Amount of pleural effusion. Timepoint: Before the study and 2 weeks after the study. Method of measurement: view.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAkram Asghari

Ghoum University of Medical Sciences

akramasghari11@yahoo.com+98 25 3612 2000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026