Effect of fluid therapy in sepsis

Comparison of two methods of restrictive fluid therapy with liberal fluid therapy in patients with sepsis hospitalized in ICU

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241105063609N1

Enrollment

Registered

2024-11-15

Start date

2024-08-22

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis. Sepsis, unspecified organism

Interventions

Intervention 1: Intervention group: Fluid therapy with normal saline until the diameter of inferior vena cava = IVC is more than 1.5 cm (liberal). Intervention 2: Intervention group: Fluid therapy wit

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Positive systemic inflammatory response syndrome

Exclusion criteria

Exclusion criteria: Lack of consent to participate in the study

Design outcomes

Primary

Measure	Time frame
C-reactive protein. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Lactate. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Procalcitonin. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;D- dimer. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Brain natriuretic peptide. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Cortisol. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.	—

Measure

Time frame

C-reactive protein. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Lactate. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Procalcitonin. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;D- dimer. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Brain natriuretic peptide. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.;Cortisol. Timepoint: intervention day, three days and 6 days after intervention. Method of measurement: Laboratory kit.

—

Secondary

Measure	Time frame
Length of stay in ICU. Timepoint: Discharge time from ICU. Method of measurement: counting days.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHasan Taghizadeh

Shahid Beheshti University of Medical Sciences

dr.h.t.forex@gmail.com00982173430

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026