Comparison of the effect of topical injection and intravenous injection of oxytocin on reducing the blood loss during myomectomy

Comparison of the effect of topical injection and intravenous injection of oxytocin on reducing the blood loss during abdominal myomectomy a randomized clinical trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20241103063575N1

Enrollment

Registered

2025-04-21

Start date

2025-01-20

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myomectomy. Intramural leiomyoma of uterus

Interventions

Intervention 1: First intervention group: Intravenous injection of oxytocin 30 IU in 500 cc Ringer at a rate of 120 cc per hour. Intervention 2: Secound intervention group: Topical (intramyometrial) i

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Age between 18 to 45 years Intramural myoma Intramural myoma grade II to VII based on FIGO Intramural myoma with a maximum size of 10 centimeters 1 to 3 intramural myoma

Exclusion criteria

Exclusion criteria: History of previous myomectomy surgery Suspected malignancy Hormonal treatment within a month before surgery Having anemia before surgery with the definition of hemoglobin less than 10 milligrams per deciliter History of coagulation disorder Uncontrolled blood pressure Taking anticoagulant drugs Thrombocytopenia Known sensitivity to oxytocin Sickle cell anemia Myomas with extensive involvement of the cervix Myomas of the posterior wall of the uterus Broad ligament myomas Adjacent visceral damage during surgery

Design outcomes

Primary

Measure	Time frame
The amount of blood lost during the operation. Timepoint: End of operation. Method of measurement: Objectively, the difference in the weight of wet gases and langaz with their dry weight (each cc of blood is equal to one gram) and the volume of blood inside the suction is recorded by the room circular. Also, the hematocrit level is checked after admission to the hospital and 1 hour after the operation.	—

Measure

Time frame

The amount of blood lost during the operation. Timepoint: End of operation. Method of measurement: Objectively, the difference in the weight of wet gases and langaz with their dry weight (each cc of blood is equal to one gram) and the volume of blood inside the suction is recorded by the room circular. Also, the hematocrit level is checked after admission to the hospital and 1 hour after the operation.

—

Secondary

Measure	Time frame
The need for additional treatments to reduce bleeding during surgery. Timepoint: During surgery. Method of measurement: Type and number of received transfusion products.;Hemoglobin difference. Timepoint: Before and after surgery. Method of measurement: Blood test.;Duration of operation. Timepoint: End of surgery. Method of measurement: Chronometer.;Duration of hospitalization. Timepoint: After discharge. Method of measurement: Register in the file.	—

Measure

Time frame

The need for additional treatments to reduce bleeding during surgery. Timepoint: During surgery. Method of measurement: Type and number of received transfusion products.;Hemoglobin difference. Timepoint: Before and after surgery. Method of measurement: Blood test.;Duration of operation. Timepoint: End of surgery. Method of measurement: Chronometer.;Duration of hospitalization. Timepoint: After discharge. Method of measurement: Register in the file.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Hashemian

Alborz University of Medical Sciences

hashemiannafiseh148@gmail.com+98 26 3419 7000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026