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The effect of losartan drops on the healing of scars caused by corneal ulcers

The effect of losartan drops on the healing of scars caused by corneal ulcers

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20241102063569N1
Enrollment
64
Registered
2024-11-04
Start date
2024-11-16
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal ulcer. Corneal ulcer

Interventions

Intervention 1: Intervention group: Patients with corneal scarring (definitive diagnosis based on the opinion of a cornea specialist with slit lamp examination and fluorescent staining) will participa

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Written informed consent to participate in the research, 2. Three to six months have passed since the healing of the corneal ulcer due to the corneal ulcer and the scar remains 3. Definite diagnosis of corneal scar based on the opinion of a corneal specialist with examination by slit lamp and fluorescent staining. . Not having any underlying diseases that require continuous medication 5. The age of patients should be between 18 and 64 years

Exclusion criteria

Exclusion criteria: 1. Allergy caused by losartan drops. 2. Corneal scar due to causes other than corneal ulcer 3. Unwillingness to participate in the intervention or unwillingness to continue the intervention 4. Absence of drug and alcohol addiction 5. Non-use of drugs that suppress the immune system 6. Lack of patient follow-up

Design outcomes

Primary

MeasureTime frame
The size of the corneal ulcer obtained from complete ophthalmological examinations (including examination with slit lamp, tonometry, imaging with corneal topography, pentacam, oct cornea, aberrometry, slit photo. Timepoint: The size of the corneal ulcer will be measured before the intervention, at the end of the intervention, i.e. three months after using the drops and six months after the intervention. Method of measurement: The size of the corneal ulcer obtained from complete ophthalmological examinations (including examination with slit lamp, tonometry, imaging with corneal topography, pentacam, oct cornea, aberrometry, slit photo.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Mohammadreza Same'

Mashhad University of Medical Sciences

mrsame1374@gmail.com+98 51 3728 1401

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026